Trial reportHead & face medicine2013
The detection of oral pre- malignant lesions with an autofluorescence based imaging system (VELscope™) - a single blinded clinical evaluation.
Trial report in Head & face medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Pooled it
- In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders-Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.The Cochrane database of systematic reviews · 2021Pooled it
- Diagnostic accuracy of clinical visualization and light-based tests in precancerous and cancerous lesions of the oral cavity and oropharynx: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association.Journal of the American Dental Association (1939) · 2017Pooled it
- Accuracy of autofluorescence in diagnosing oral squamous cell carcinoma and oral potentially malignant disorders: a comparative study with aero-digestive lesions.Scientific reports · 2016Pooled it
- Efficacy of light based detection systems for early detection of oral cancer and oral potentially malignant disorders: Systematic review.Medicina oral, patologia oral y cirugia bucal · 2016Pooled it
- Non-invasive visual tools for diagnosis of oral cancer and dysplasia: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2016Pooled it
- Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review.Medicina oral, patologia oral y cirugia bucal · 2015Pooled it
- Efficacy of non-invasive diagnostic methods in the diagnosis and screening of oral cancer and precancer.Brazilian journal of otorhinolaryngologyPooled it
- Article
- Evaluating the Role of VELscope in Oral Cancer and Pre-Cancer Screening: A Scoping Review.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Effectiveness of adjunctive screening tools for potentially malignant oral disorders and oral cancer: A systematic review.The Saudi dental journal · 2024Review
- Light-Based Non-Invasive Techniques as Diagnostic Tools in Cancer Detection: A Systematic Review.Journal of pharmacy & bioallied sciences · 2023Article
- Autofluorescence Image-Guided Endoscopy in the Management of Upper Aerodigestive Tract Tumors.International journal of environmental research and public health · 2022Review
- Applications of Laser-Induced Fluorescence in Medicine.Sensors (Basel, Switzerland) · 2022Article
- Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study.Journal of biomedical optics · 2020Article
- Review
- Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues.Molecules (Basel, Switzerland) · 2020Review
- From honest mistakes to fake news - approaches to correcting the scientific literature.Head & face medicine · 2020Article
Corrections and comments
- Erratum issuedAssaf, Alexandre Thomas [added]
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe disease specific five-year survival rate especially for patients with advanced oral cancer has not improved significantly over the period of time. The most effective way of combating this dilemma is an early detection, diagnosis and eradication of early-stage lesions and their precursors. The use of VELscope® using an autofluorescence as a diagnostic tool might be useful in early detection of oral malignant lesions. MATERIALS AND
methods120 patients with suspicious oral premalignant lesions were examined with two examination methods. They were randomly divided into two groups. Group 1 was examined conventional with white-light and group 2 was examined additionally to the white-light-examination with an autofluorescence visualization device, VELscope®. Biopsies were obtained from all suspicious areas identified in both examination groups (n = 52). The diagnostic strategies were compared regarding sensitivity and specificity.
resultsBased upon the result, use of the VELscope® leads to a higher sensitivity (22.0%), but regarding specificity the additional use of the VELscope® is inferior (8.4%).
conclusionThe VELscope device is a simple, non-invasive test of the oral mucosa, which can help the experienced clinician to find oral precursor malignant lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.