ArticleFrontiers in cellular and infection microbiology2013
Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease.
Article in Frontiers in cellular and infection microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Cost of illness in patients with post-treatment Lyme disease syndrome in Belgium.European journal of public health · 2023Article
- Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries.Frontiers in pharmacology · 2022Article
- Sexual Transmission of Lyme Borreliosis? The Question That Calls for an Answer.Tropical medicine and infectious disease · 2021Article
- Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease.Healthcare (Basel, Switzerland) · 2018Article
- Spirochetal Lipoproteins and Immune Evasion.Frontiers in immunology · 2017Review
- Review
- The anti-borreliae efficacy of phytochemicals and micronutrients: an update.Therapeutic advances in infectious disease · 2016Review
- Lyme disease: the promise of Big Data, companion diagnostics and precision medicine.Infection and drug resistance · 2016Article
- Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp.International journal of biological sciences · 2016Article
- Relevance of chronic lyme disease to family medicine as a complex multidimensional chronic disease construct: a systematic review.International journal of family medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lyme disease is the most common tickborne illness in the world today. A recent study describes for the first time an enzyme produced by the spirochetal agent of Lyme disease, Borrelia burgdorferi, that cleaves aggrecan, a proteoglycan found in joints and connective tissue. Discovery of the spirochetal aggrecanase raises many questions about the pathogenesis of Lyme arthritis and lends support to the concept of persistent B. burgdorferi infection in patients with chronic Lyme disease symptoms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.