ArticleFrontiers in oncology2013
Ultrasonic enhancement of drug penetration in solid tumors.
Article in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Enhanced model antigen retention in tissue through topical high-frequency ultrasound treatment.Biomedical engineering letters · 2025Article
- Therapeutic Ultrasound Parameter Optimization for Drug Delivery Applied to a Murine Model of Hepatocellular Carcinoma.Ultrasound in medicine & biology · 2021Article
- In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Enhanced microbubble contrast agent oscillation following 250 kHz insonation.Scientific reports · 2018Article
- Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue.International journal of nanomedicine · 2018Article
- Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery.Neuro-oncology · 2016Review
- A Review of Thermo- and Ultrasound-Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents.Polymers · 2016Review
- Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy.Expert opinion on drug delivery · 2016Review
- Magnetic Resonance-Guided Drug Delivery.Magnetic resonance imaging clinics of North America · 2015Review
- DDMC-p53 gene therapy with or without cisplatin and microwave ablation.OncoTargets and therapy · 2015Article
- Targeted Mesoporous Iron Oxide Nanoparticles-Encapsulated Perfluorohexane and a Hydrophobic Drug for Deep Tumor Penetration and Therapy.Theranostics · 2015Article
- Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles.Advanced drug delivery reviews · 2014Review
- Article
- A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery.PloS one · 2014Article
- Optical clearing in photoacoustic flow cytometry.Biomedical optics express · 2013Article
- Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
- Mechanical Microenvironment-Dependent Tumor Growth Intervention: Recent Advances and Translational Outlook.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Increasing the penetration of drugs within solid tumors can be accomplished through multiple ultrasound-mediated mechanisms. The application of ultrasound can directly change the structure or physiology of tissues or can induce changes in a drug or vehicle in order to enhance delivery and efficacy. With each ultrasonic pulse, a fraction of the energy in the propagating wave is absorbed by tissue and results in local heating. When ultrasound is applied to achieve mild hyperthermia, the thermal effects are associated with an increase in perfusion or the release of a drug from a temperature-sensitive vehicle. Higher ultrasound intensities locally ablate tissue and result in increased drug accumulation surrounding the ablated region of interest. Further, the mechanical displacement induced by the ultrasound pulse can result in the nucleation, growth and collapse of gas bubbles. As a result of such cavitation, the permeability of a vessel wall or cell membrane can be increased. Finally, the radiation pressure of the propagating pulse can translate particles or tissues. In this perspective, we will review recent progress in ultrasound-mediated tumor delivery and the opportunities for clinical translation.
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Registered trials
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