ArticlePLoS neglected tropical diseases2013
Helminthic infections rates and malaria in HIV-infected pregnant women on anti-retroviral therapy in Rwanda.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Malaria prevalence in HIV-positive children, pregnant women, and adults: a systematic review and meta-analysis.Parasites & vectors · 2022Pooled it
- Water, sanitation, hygiene, and soil-transmitted helminth infection: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review.Health science reports · 2025Review
- Review
- Exploration of iron deficiency anemia and its associated factors among pregnant women seeking antenatal care in public health facilities of southwestern Ethiopia. A mixed study.AJOG global reports · 2024Article
- Herpes simplex virus type 2 in sub-Saharan Africa and the potential impact of helminth immune modulation.Frontiers in cellular and infection microbiology · 2024Review
- Burden of intestinal parasitic infections and associated factors among pregnant women in East Africa: a systematic review and meta-analysis.Maternal health, neonatology and perinatology · 2023Review
- Equal contributions of feline immunodeficiency virus and coinfections to morbidity in African lions.International journal for parasitology. Parasites and wildlife · 2021Article
- Malaria, Helminth Infections and Clinical Status Among HIV-Infected Pregnant Women.International journal of MCH and AIDS · 2021Article
- Canine Gastrointestinal Nematodiases and Associated Risk Factors in Kigali City, Rwanda.Journal of parasitology research · 2021Article
- Associations of malaria, HIV, and coinfection, with anemia in pregnancy in sub-Saharan Africa: a population-based cross-sectional study.BMC pregnancy and childbirth · 2020Article
- Effects of malaria/helminthic coinfections on cervical cancer progression among sub Saharan African women on highly active antiretroviral therapy: A scoping review.Gynecologic oncology reports · 2019Article
- The Consequences of Mixed-Species Malaria Parasite Co-Infections in Mice and Mosquitoes for Disease Severity, Parasite Fitness, and Transmission Success.Frontiers in immunology · 2019Article
- Prevalence and associated factors ofAfrican health sciences · 2018Article
- Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon.PLoS neglected tropical diseases · 2018Article
- Anemia in people on second line antiretroviral treatment in Lilongwe, Malawi: a cross-sectional study.BMC infectious diseases · 2018Article
- Malaria and HIV coinfection in sub-Saharan Africa: prevalence, impact, and treatment strategies.Research and reports in tropical medicine · 2018Review
- Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018Article
- Parasitic infections and maternal anaemia among expectant mothers in the Dangme East District of Ghana.BMC research notes · 2017Article
- Coinfection withJournal of parasitology research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWithin sub-Saharan Africa, helminth and malaria infections cause considerable morbidity in HIV-positive pregnant women and their offspring. Helminth infections are also associated with a higher risk of mother-to-child HIV transmission. The aim of this study was to determine the prevalence of, and the protective and risk factors for helminth and malaria infections in pregnant HIV-positive Rwandan women receiving anti-retroviral therapy (ART). METHODOLOGY AND PRINCIPLE
findingsPregnant females (n = 980) were recruited from health centres in rural and peri-urban locations in the central and eastern provinces of Rwanda. Helminth infection was diagnosed using the Kato Katz method whilst the presence of Plasmodium falciparum was identified from blood smears. The prevalence of helminth infections was 34.3%; of malaria 13.3%, and of co-infections 6.6%. Helminth infections were more common in rural (43.1%) than peri-urban (18.0%; p<0.0005) sites. A CD4 count ≤ 350 cells/mm(3) was associated with a higher risk of helminth infections (odds ratio, 3.39; 95% CIs, 2.16-5.33; p<0.0005) and malaria (3.37 [2.11-5.38]; p<0.0005) whilst helminth infection was a risk factor for malaria infection and vice versa. Education and employment reduced the risk of all types of infection whilst hand washing protected against helminth infection (0.29 [0.19-0.46]; p<0.0005);). The TDF-3TC-NVP (3.47 [2.21-5.45]; p<0.0005), D4T-3TC-NVP (2.47 [1.27-4.80]; p<0.05) and AZT-NVP (2.60 [1.33-5.08]; p<0.05) regimens each yielded higher helminth infection rates than the AZT-3TC-NVP regimen. Anti-retroviral therapy had no effect on the risk of malaria. CONCLUSION/SIGNIFICANCE: HIV-positive pregnant women would benefit from the scaling up of de-worming programs alongside health education and hygiene interventions. The differential effect of certain ART combinations (as observed here most strongly with AZT-3TC-NVP) possibly protecting against helminth infection warrants further investigation.
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