ArticlePLoS neglected tropical diseases2013
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Microbiome-mediated chemical communication in insects: Implications for pest management.Pest management science · 2026Review
- Bacterial Symbionts Associated with Wild Tsetse Flies (Diptera: Glossinidae) in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Prevalence of trypanosomes and selected symbionts in tsetse species of eastern Zambia.Parasitology · 2022Article
- Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors.Parasites & vectors · 2022Review
- Prevalence of Trypanosoma and Sodalis in wild populations of tsetse flies and their impact on sterile insect technique programmes for tsetse eradication.Scientific reports · 2022Article
- A machine learning approach to integrating genetic and ecological data in tsetse flies (Evolutionary applications · 2021Article
- Aerobic midgut microbiota of sand fly vectors of zoonotic visceral leishmaniasis from northern Iran, a step toward finding potential paratransgenic candidates.Parasites & vectors · 2019Article
- Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives.BMC microbiology · 2018Article
- Analysis of the gut-specific microbiome from field-captured tsetse flies, and its potential relevance to host trypanosome vector competence.BMC microbiology · 2018Article
- Tsetse fly (Glossina pallidipes) midgut responses to Trypanosoma brucei challenge.Parasites & vectors · 2017Article
- First detection of Wolbachia-infected Culicoides (Diptera: Ceratopogonidae) in Europe: Wolbachia and Cardinium infection across Culicoides communities revealed in Spain.Parasites & vectors · 2017Article
- Microbial control of arthropod-borne disease.Memorias do Instituto Oswaldo Cruz · 2017Review
- Coxiella symbionts are widespread into hard ticks.Parasitology research · 2016Article
- Forecasting Human African Trypanosomiasis Prevalences from Population Screening Data Using Continuous Time Models.PLoS computational biology · 2016Article
- Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis.PLoS neglected tropical diseases · 2016Article
- Evaluating long-term effectiveness of sleeping sickness control measures in Guinea.Parasites & vectors · 2015Article
- A comparative analysis of reproductive biology of insect vectors of human disease.Current opinion in insect science · 2015Article
- Adult blood-feeding tsetse flies, trypanosomes, microbiota and the fluctuating environment in sub-Saharan Africa.The ISME journal · 2015Review
- Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner.PLoS neglected tropical diseases · 2015Article
- Aerobic bacterial flora of biotic and abiotic compartments of a hyperendemic Zoonotic Cutaneous Leishmaniasis (ZCL) focus.Parasites & vectors · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal symbiotic bacteria Sodalis to express trypanosome-resistance-conferring products. Modified Sodalis can then be driven into the tsetse population by cytoplasmic incompatibility (CI) from Wolbachia bacteria. To evaluate the effectiveness of this paratransgenic strategy in controlling African trypanosomiasis, we developed a three-species mathematical model of trypanosomiasis transmission among tsetse, humans, and animal reservoir hosts. Using empirical estimates of CI parameters, we found that paratransgenic tsetse have the potential to eliminate trypanosomiasis, provided that any extra mortality caused by Wolbachia colonization is low, that the paratransgene is effective at protecting against trypanosome transmission, and that the target tsetse species comprises a large majority of the tsetse population in the release location.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.