ArticlePloS one2013
Hyperbaric hyperoxia accelerates fracture healing in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effects of hyperbaric oxygen therapy on bone, muscle, cartilage, tendon and ligaments in animal studies: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Effects of hyperbaric oxygen therapy on human musculoskeletal pathologies in clinical studies: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- The effect of hyperbaric oxygen and platelet-rich plasma treatments on the adipogenic C2C12 myoblast cell line.BMC musculoskeletal disorders · 2025Article
- Hyperbaric Oxygen Treatment Ameliorates the Decline in Oocyte Quality and Improves the Fertility of Aged Female Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Hyperbaric oxygen therapy efficacy on mandibular defect regeneration in rats with diabetes mellitus: an animal study.BMC oral health · 2023Article
- 3D-printed oxygen-releasing scaffolds improve bone regeneration in mice.Biomaterials · 2022Article
- Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study.International journal of environmental research and public health · 2020Article
- The effect of hyperbaric oxygen therapy on bone macroscopy, composition and biomechanical properties after ionizing radiation injury.Radiation oncology (London, England) · 2020Article
- Adjunctive hyperbaric oxygen therapy for irradiated rat calvarial defects.Journal of periodontal & implant science · 2019Article
- Influence of hyperbaric oxygen on biomechanics and structural bone matrix in type 1 diabetes mellitus rats.PloS one · 2018Article
- Effect of hyperbaric oxygen therapy (HBO) on implant-associated osteitis in a femur fracture model in mice.PloS one · 2018Article
- Endurance performance is enhanced by intermittent hyperbaric exposure via up-regulation of proteins involved in mitochondrial biogenesis in mice.Physiological reports · 2017Article
- Osteogenic Differentiation of Periosteal Cells During Fracture Healing.Journal of cellular physiology · 2017Review
- Impairment of cold injury-induced muscle regeneration in mice receiving a combination of bone fracture and alendronate treatment.PloS one · 2017Article
- Article
- The impact of hyperbaric hyperoxia on fracture repair.BoneKEy reports · 2013Article
- Development of a novel murine femur fracture and fixation model.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased oxygen tension influences bone metabolism. This study comprised two main experiments: one aimed to determine the bone mineral apposition and bone formation rates in vivo under hyperbaric hyperoxia (HBO), and the other aimed to evaluate the effects of exposure to HBO on fracture healing. In experiment 1, male mice were exposed to HBO [90 min/day at 90% O₂ at 2 atmospheres absolute (ATA) for 5 days]. In experiment 2, an open femur fracture model was created in mice, followed by exposure to HBO 5 times/week (90 min/day at 90% O₂ at 2 ATA) for 6 weeks after surgery. In experiment 1, HBO treatment significantly increased the mineral apposition and bone formation rates in the lumbar vertebra and femur and type 1 collagen alpha 1 and alkaline phosphatase mRNA expression in the lumbar vertebra. In experiment 2, at 2 weeks after fracture, the fracture callus was significantly larger in the HBO group than in the non-HBO group. Furthermore, at 4 and 6 weeks after fracture, radiographic findings showed accelerated fracture healing in the HBO group. At 6 weeks after fracture, femur stiffness and maximum load were significantly higher in the HBO group than in the non-HBO group. Urinary 8-hydroxy-2'-deoxyguanosine and plasma calcium concentrations were not significantly different between groups. These results suggest that exposure to HBO enhances bone anabolism and accelerates fracture healing without causing oxidative DNA damage or disruption of plasma calcium homeostasis.
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