ArticlePloS one2013
Differential associations of depressive symptom dimensions with cardio-vascular disease in the community: results from the Gutenberg health study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Similarities and Differences of Mental Health in Women and Men: A Systematic Review of Findings in Three Large German Cohorts.Frontiers in public health · 2021Pooled it
- Exploring the multiverse: the impact of researchers' analytic decisions on relationships between depression and inflammatory markers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study.BMC psychiatry · 2023Article
- Anxiety and depression symptoms, albuminuria and risk of acute myocardial infarction in the Norwegian HUNT cohort study.BMC cardiovascular disorders · 2022Article
- Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms.Brain, behavior, & immunity - health · 2022Article
- Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women.Frontiers in psychiatry · 2022Article
- Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies.BMC psychiatry · 2021Article
- Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort.Scientific reports · 2021Article
- Inflammation and the dimensions of depression: A review.Frontiers in neuroendocrinology · 2020Review
- Depressive symptom dimensions and medication non-adherence in suboptimally controlled type 2 diabetes.Journal of diabetes and its complications · 2019Article
- Correlation of clinical features with hs-CRP in TRD patients.Experimental and therapeutic medicine · 2019Article
- Associations between degree and sub-dimensions of depression and metabolic syndrome (MetS) in the community: results from the Gutenberg Health Study (GHS).BMC psychiatry · 2018Article
- Associations of fatigue to work-related stress, mental and physical health in an employed community sample.BMC psychiatry · 2017Article
- Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study.Scientific reports · 2017Article
- Tangled Up in Blue: Unraveling the Links Between Emotional Distress and Treatment Adherence in Type 2 Diabetes.Diabetes care · 2016Article
- Late-life depression and cardiovascular disease burden: examination of reciprocal relationship.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Chronic stress impairs collateral blood flow recovery in aged mice.Journal of cardiovascular translational research · 2014Article
- Felt age and cognitive-affective depressive symptoms in late life.Aging & mental health · 2014Article
- Article
- Associations between depression and diabetes in the community: do symptom dimensions matter? Results from the Gutenberg Health Study.PloS one · 2014Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A current model suggested that the somatic symptom dimension accounts for the adverse effect of depression in patients with coronary heart disease (CHD). In order to test this model we sought to determine in a large population-based sample how symptom dimensions of depression are associated with CHD, biomarkers and traditional risk factors. The associations of cognitive and somatic symptom dimensions of depression with CHD, risk factors, endothelial function, and biomarkers of inflammation and myocardial stress were analyzed cross-sectionally in a sample of n = 5000 Mid-Europeans aged 35-74 years from the Gutenberg Health Study (GHS). Only the somatic symptom dimension of depression was associated with CHD, biomarkers (inflammation, vascular function) and cardio-vascular risk factors. When multivariable adjustment was applied by demographic and cardiovascular risk factors, the weak associations of the somatic symptom dimension with the biomarkers disappeared. However, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained. Both dimensions of depression were independently associated with a previous diagnosis of depression and distressed personality (type D). Thus, our results partly confirm current models: Somatic, but not cognitive-affective symptom dimensions are responsible for the association between depression and CHD, inflammation, vascular function and cardiovascular risk factors in the general population. However, our findings challenge the assumptions that somatic depression might be due to inflammation or vascular dysfunction as consequence of progressed atherosclerotic disease. They rather emphasize a close interplay with life-style factors and with a family history of MI.
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