Evidence map›Paper›PMID 23967255›Full record

ArticlePloS one2013

Primary drug-resistant tuberculosis in Hanoi, Viet Nam: present status and risk factors.

Nguyen Thi Le Hang, Shinji Maeda, Luu Thi Lien, Pham Huu Thuong, Nguyen Van Hung, Tran Bich Thuy, Akiko Nanri, Tetsuya Mizoue, Nguyen Phuong Hoang, Vu Cao Cuong and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 6 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  17. The American journal of tropical medicine and hygiene · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Nguyen Thi Le HangNCGM-BMH Medical Collaboration Center, Hanoi, Viet Nam.
Shinji Maeda
Luu Thi Lien
Pham Huu Thuong
Nguyen Van Hung
Tran Bich Thuy
Akiko Nanri
Tetsuya Mizoue
Nguyen Phuong Hoang
Vu Cao Cuong
Khieu Thi Thuy Ngoc
Shinsaku Sakurada
Hiroyoshi Endo
Naoto Keicho
Hanoi Lung Hospital · VNNational Center for Global Health and Medicine · JPJapan Anti Tuberculosis Association · JPHanoi School Of Public Health · VNTokyo Women's Medical University · JPVietnamese - German Center of Excellence in Medical Research · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResistance of Mycobacterium tuberculosis (MTB) to anti-tuberculosis (TB) drugs presents a serious challenge to TB control worldwide. We investigated the status of drug resistance, including multidrug-resistant (MDR) TB, and possible risk factors among newly diagnosed TB patients in Hanoi, the capital of Viet Nam.

methodsClinical and epidemiological information was collected from 506 newly diagnosed patients with sputum smear- and culture-positive TB, and 489 (96.6%) MTB isolates were subjected to conventional drug susceptibility testing, spoligotyping, and 15-locus variable numbers of tandem repeats typing. Adjusted odds ratios (aORs) were calculated to analyze the risk factors for primary drug resistance.

resultsOf 489 isolates, 298 (60.9%) were sensitive to all drugs tested. Resistance to isoniazid, rifampicin, streptomycin, ethambutol, and MDR accounted for 28.2%, 4.9%, 28.2%, 2.9%, and 4.5%, respectively. Of 24 isolates with rifampicin resistance, 22 (91.7%) were MDR and also resistant to streptomycin, except one case. Factors associated with isoniazid resistance included living in old urban areas, presence of the Beijing genotype, and clustered strains [aOR = 2.23, 95% confidence interval (CI) 1.15-4.35; 1.91, 1.18-3.10; and 1.69, 1.06-2.69, respectively). The Beijing genotype was also associated with streptomycin resistance (aOR = 2.10, 95% CI 1.29-3.40). Human immunodeficiency virus (HIV) coinfection was associated with rifampicin resistance and MDR (aOR = 5.42, 95% CI 2.07-14.14; 6.23, 2.34-16.58, respectively).

conclusionIsoniazid and streptomycin resistance was observed in more than a quarter of TB patients without treatment history in Hanoi. Transmission of isoniazid-resistant TB among younger people should be carefully monitored in urban areas, where Beijing strains and HIV coinfection are prevalent. Choosing an optimal treatment regimen on the basis of the results of drug susceptibility tests and monitoring of treatment adherence would minimize further development of drug resistance strains.

Indexed as

AdolescentAdultAgedAged, 80 and overAntitubercular AgentsCoinfectionDrug Resistance, Multiple, BacterialFemaleGenotypeHIV InfectionsHumansMaleMiddle AgedMycobacterium tuberculosisOdds RatioPrevalenceAntitubercular Agents

Identifiers

PMID23967255
PMCPMC3742467
OpenAlexW1996233765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.