SynthesisPloS one2013
Hormone replacement therapy in females can decrease the risk of lung cancer: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Menopausal hormone therapy and women's health: An umbrella review.PLoS medicine · 2021Pooled it
- Pooled it
- Pooled it
- Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2015Pooled it
- Estrogen Plus Progestin and Lung Cancer: Follow-up of the Women's Health Initiative Randomized Trial.Clinical lung cancer · 2016Trial
- Age at first sexual intercourse, age at menarche, and age at menopause: a mendelian randomization study on lung cancer risk.Translational lung cancer research · 2024Article
- Endogenous sex hormones, aromatase activity and lung cancer risk in postmenopausal never-smoking women.International journal of cancer · 2022Article
- The association between different hormone replacement therapy use and the incidence of lung cancer: a systematic review and meta-analysis.Journal of thoracic disease · 2022Article
- Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC).BMC cancer · 2020Article
- Risk of Second Lung Cancer in Patients with Previously Treated Lung Cancer: Analysis of Surveillance, Epidemiology, and End Results (SEER) Data.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2018Article
- Menopausal Hormone Therapy, Age, and Chronic Diseases: Perspectives on Statistical Trends.Chemical research in toxicology · 2016Review
- Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.Cancer control : journal of the Moffitt Cancer Center · 2016Article
- Nothing Boring About Boron.Integrative medicine (Encinitas, Calif.) · 2015Review
- Hormone Use, Reproductive History, and Risk of Lung Cancer: The Women's Health Initiative Studies.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Article
- Modifiable risk factors of lung cancer in "never-smoker" women.Epidemiology and health · 2015Article
- Elevated pretreatment serum globulin albumin ratio predicts poor prognosis for advanced non-small cell lung cancer patients.Journal of thoracic disease · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present meta-analysis was to determine the relationship between hormone replacement therapy (HRT) and lung cancer risk in females. Publications were reviewed and obtained through a PubMed, EMBASE database and Cochrane Library literature search up to May, 2012. The detailed numbers of patients in different groups, odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were collected and estimated using a random-effects model. Twenty five studies entered into the meta-analysis. The total number of participates and lung cancer patients was 656,403 and 11,442, respectively. The OR of all 25 studies was 0.91 (95%CI = 0.83 to 0.99) and P value was 0.033. In stratified analyses, the positive association between HRT use and decreased lung cancer risk was also found in the patients with BMI<25 kg/m² (OR = 0.65, P = 0.000), and never smokers patients (OR = 0.86, P = 0.042). However, HRT use in patients with artificial menopause could increase the lung cancer risk, OR = 1.51(P = 0.001). The result of Egger's test did not show any evidence of publican bias (P = 0.069). In conclusion, our meta-analysis on HRT and lung cancer risk suggests that HRT use is correlated with decreased lung cancer risk in female, especially in female with BMI<25 kg/m² and never smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.