ArticlePloS one2013
Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson's disease patient iPSC derived midbrain neurons.Nature communications · 2024Article
- An Update on the Critical Role of α-Synuclein in Parkinson's Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels.Molecular neurobiology · 2022Review
- Roles for α-Synuclein in Gene Expression.Genes · 2021Review
- Vesicle trafficking and lipid metabolism in synucleinopathy.Acta neuropathologica · 2021Review
- Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Communications biology · 2021Article
- Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner.International journal of molecular sciences · 2021Article
- Parkinson's disease laterality: aJournal of neurology · 2021Article
- Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum.Life (Basel, Switzerland) · 2020Article
- LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?Frontiers in neuroscience · 2020Review
- Is Parkinson's disease a lysosomal disorder?Brain : a journal of neurology · 2018Article
- Subcellular localization of alpha-synuclein aggregates and their interaction with membranes.Neural regeneration research · 2018Review
- The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease.Brain, behavior, and immunity · 2018Review
- Alpha-synuclein modulates dopamine neurotransmission.Journal of chemical neuroanatomy · 2017Review
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine · 2017Review
- Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.PloS one · 2017Article
- Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.Movement disorders : official journal of the Movement Disorder Society · 2016Review
- Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Biomolecules · 2015Review
- Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease.Frontiers in neuroscience · 2015Review
- Parallel mechanisms for direct and indirect membrane protein trafficking by synucleins.Communicative & integrative biology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Synaptic re-uptake of dopamine is dependent on the dopamine transporter (DAT), which is regulated by its distribution to the cell surface. DAT trafficking is modulated by the Parkinson's disease-linked protein alpha-synuclein, but the contribution of synuclein family members beta-synuclein and gamma-synuclein to DAT trafficking is not known. Here we use SH-SY5Y cells as a model of DAT trafficking to demonstrate that all three synucleins negatively regulate cell surface distribution of DAT. Under these conditions the synucleins limit export of DAT from the endoplasmic reticulum (ER) by impairment of the ER-Golgi transition, leading to accumulation of DAT in this compartment. This mechanism for regulating DAT export indirectly through effects on ER and Golgi function represents a previously unappreciated role for the extended synuclein family that is likely applicable to trafficking of the many proteins that rely on the secretory pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.