Trial reportPloS one2013
The effect of aerobic exercise on intrahepatocellular and intramyocellular lipids in healthy subjects.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00491582 (The Effect of Growth Hormone), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Growth Hormone (GH) on Intramyocellular Lipids (IMCL), Intrahepatocellular Lipids (IHCL) and Visceral Fat Mass in Relation to Insulin Resistance
Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Intramyocellular lipid accumulation after sprint interval and moderate-intensity continuous training in healthy and diabetic subjects.Physiological reports · 2019Trial
- Trial
- Effect ofNutrients · 2022Article
- Plasma Free Fatty Acid Concentration as a Modifiable Risk Factor for Metabolic Disease.Nutrients · 2021Review
- Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner.Lipids in health and disease · 2020Article
- Exercising your fat (metabolism) into shape: a muscle-centred view.Diabetologia · 2020Review
- Determinants of ectopic liver fat in metabolic disease.European journal of clinical nutrition · 2019Review
- Relationship between physical activity and intramyocellular lipid content is different between young and older adults.European journal of applied physiology · 2019Article
- The Flexibility of Ectopic Lipids.International journal of molecular sciences · 2016Review
- Review
- Effects of aerobic exercise on ectopic lipids in patients with growth hormone deficiency before and after growth hormone replacement therapy.Scientific reports · 2016Article
- Article
- Acute exercise does not decrease liver fat in men with overweight or NAFLD.Scientific reports · 2015Article
- Measuring short-term liver metabolism non-invasively: postprandial and post-exercise ¹H and ³¹P MR spectroscopy.Magma (New York, N.Y.) · 2015Article
- Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention.Physiological reports · 2014Article
- The effect of a single 2 h bout of aerobic exercise on ectopic lipids in skeletal muscle, liver and the myocardium.Diabetologia · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntrahepatocellular (IHCL) and intramyocellular (IMCL) lipids are ectopic lipid stores. Aerobic exercise results in IMCL utilization in subjects over a broad range of exercise capacity. IMCL and IHCL have been related to impaired insulin action at the skeletal muscle and hepatic level, respectively. The acute effect of aerobic exercise on IHCL is unknown. Possible regulatory factors include exercise capacity, insulin sensitivity and fat availability subcutaneous and visceral fat mass).
aimTo concomitantly investigate the effect of aerobic exercise on IHCL and IMCL in healthy subjects, using Magnetic Resonance spectroscopy.
methodsNormal weight, healthy subjects were included. Visit 1 consisted of a determination of VO2max on a treadmill. Visit 2 comprised the assessment of hepatic and peripheral insulin sensitivity by a two-step hyperinsulinaemic euglycaemic clamp. At Visit 3, subcutaneous and visceral fat mass were assessed by whole body MRI, IHCL and IMCL before and after a 2-hours aerobic exercise (50% of VO(2max)) using ¹H-MR-spectroscopy.
resultsEighteen volunteers (12M, 6F) were enrolled in the study (age, 37.6±3.2 years, mean±SEM; VO(2max), 53.4±2.9 mL/kg/min). Two hours aerobic exercise resulted in a significant decrease in IMCL (-22.6±3.3, % from baseline) and increase in IHCL (+34.9±7.6, % from baseline). There was no significant correlation between the exercise-induced changes in IMCL and IHCL and exercise capacity, subcutaneous and visceral fat mass and hepatic or peripheral insulin sensitivity.
conclusionsIMCL and IHCL are flexible ectopic lipid stores that are acutely influenced by physical exercise, albeit in different directions.
trial registrationClinicalTrial.gov NCT00491582.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.