ArticlePloS one2013
Discovery of J chain in African lungfish (Protopterus dolloi, Sarcopterygii) using high throughput transcriptome sequencing: implications in mucosal immunity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Impact of transportation in freshwater and brackish water on Nile tilapia (Oreochromis niloticus) resistance.BMC veterinary research · 2024Article
- The immunoglobulin J chain is an evolutionarily co-opted chemokine.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The lungfish cocoon is a living tissue with antimicrobial functions.Science advances · 2021Article
- Vaccination Route Determines the Kinetics and Magnitude of Nasal Innate Immune Responses in Rainbow Trout (Biology · 2020Article
- Article
- Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST.Chemical senses · 2019Article
- Article
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea.TheScientificWorldJournal · 2019Article
- Effects of Experimental Terrestrialization on the Skin Mucus Proteome of African Lungfish (Frontiers in immunology · 2018Article
- CK12a, a CCL19-like Chemokine That Orchestrates both Nasal and Systemic Antiviral Immune Responses in Rainbow Trout.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Symbiont-derived sphingolipids modulate mucosal homeostasis and B cells in teleost fish.Scientific reports · 2016Article
- Tissue Microenvironments in the Nasal Epithelium of Rainbow Trout (Oncorhynchus mykiss) Define Two Distinct CD8α+ Cell Populations and Establish Regional Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Transcriptomic Insights into the Response of Placenta and Decidua Basalis to the CpG Oligodeoxynucleotide Stimulation in Non-Obese Diabetic Mice and Wild-Type Controls.International journal of molecular sciences · 2016Article
- An attenuated virus vaccine appears safe to the central nervous system of rainbow trout (Oncorhynchus mykiss) after intranasal delivery.Fish & shellfish immunology · 2016Article
- Topographical Mapping of the Rainbow Trout (Oncorhynchus mykiss) Microbiome Reveals a Diverse Bacterial Community with Antifungal Properties in the Skin.Applied and environmental microbiology · 2015Article
- African Lungfish Reveal the Evolutionary Origins of Organized Mucosal Lymphoid Tissue in Vertebrates.Current biology : CB · 2015Article
- Effects of transportation stress and addition of salt to transport water on the skin mucosal homeostasis of rainbow trout (Aquaculture (Amsterdam, Netherlands) · 2015Article
- Nasal immunity is an ancient arm of the mucosal immune system of vertebrates.Nature communications · 2014Article
- Putting J chain back on the map: how might its expression define plasma cell development?Journal of immunology (Baltimore, Md. : 1950) · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
J chain is a small polypeptide responsible for immunoglobulin (Ig) polymerization and transport of Igs across mucosal surfaces in higher vertebrates. We identified a J chain in dipnoid fish, the African lungfish (Protopterus dolloi) by high throughput sequencing of the transcriptome. P. dolloi J chain is 161 aa long and contains six of the eight Cys residues present in mammalian J chain. Phylogenetic studies place the lungfish J chain closer to tetrapod J chain than to the coelacanth or nurse shark sequences. J chain expression occurs in all P. dolloi immune tissues examined and it increases in the gut and kidney in response to an experimental bacterial infection. Double fluorescent in-situ hybridization shows that 88.5% of IgM⁺ cells in the gut co-express J chain, a significantly higher percentage than in the pre-pyloric spleen. Importantly, J chain expression is not restricted to the B-cell compartment since gut epithelial cells also express J chain. These results improve our current view of J chain from a phylogenetic perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.