ArticleFrontiers in genetics2013
Sarcopenia and piscines: the case for indeterminate-growing fish as unique genetic model organisms in aging and longevity research.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Chronic Cortisol Exposure Reshapes Chromatin Accessibility and Gene Expression: Implications for Growth and Welfare in Rainbow Trout (International journal of molecular sciences · 2026Article
- Zebrafish relatives as models for functional comparative genetics and genomics.Nature reviews. Genetics · 2026Review
- Declining muscle hyperplasia in juvenile trout is associated with a significant impairment of the supportive function of the myogenic progenitor niche.Skeletal muscle · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 13. Fish soft tissues.Journal of toxicologic pathology · 2026Article
- Phenotypic plasticity in fish cell lines: conceptual links to aquatic epigenetics.Frontiers in epigenetics and epigenomics · 2026Review
- Specific cell states underlie complex tissue regeneration in spiny mice.bioRxiv : the preprint server for biology · 2025Article
- Article
- CaThe FEBS journal · 2022Article
- Histological and biochemical evaluation of skeletal muscle in the two salmonid species Coregonus maraena and Oncorhynchus mykiss.PloS one · 2021Article
- Skeletal Muscle and the Effects of Ammonia Toxicity in Fish, Mammalian, and Avian Species: A Comparative Review Based on Molecular Research.International journal of molecular sciences · 2020Review
- Zebrafish models of sarcopenia.Disease models & mechanisms · 2020Review
- Ageing impacts phenotypic flexibility in an air-acclimated amphibious fish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Genome-Wide Association Study for Identifying Loci that Affect Fillet Yield, Carcass, and Body Weight Traits in Rainbow Trout (Frontiers in genetics · 2016Article
- Characterisation and expression analysis of cathepsins and ubiquitin-proteasome genes in gilthead sea bream (Sparus aurata) skeletal muscle.BMC research notes · 2015Article
- Phylogeny of zebrafish, a "model species," within Danio, a "model genus".Molecular biology and evolution · 2015Article
- Evolutionary history and epigenetic regulation of the three paralogous pax7 genes in rainbow trout.Cell and tissue research · 2015Article
Corrections and comments
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5 authors.
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Abstract
Sarcopenia and dynapenia pose significant problems for the aged, especially as life expectancy rises in developed countries. Current therapies are marginally efficacious at best, and barriers to breakthroughs in treatment may result from currently employed model organisms. Here, we argue that the use of indeterminate-growing teleost fish in skeletal muscle aging research may lead to therapeutic advancements not possible with current mammalian models. Evidence from a comparative approach utilizing the subfamily Danioninae suggests that the indeterminate growth paradigm of many teleosts arises from adult muscle stem cells with greater proliferative capacity, even in spite of smaller progenitor populations. We hypothesize that paired-box transcription factors, Pax3/7, are involved with this enhanced self-renewal and that prolonged expression of these factors may allow some fish species to escape, or at least forestall, sarcopenia/dynapenia. Future research efforts should focus on the experimental validation of these genes as key factors in indeterminate growth, both in the context of muscle stem cell proliferation and in prevention of skeletal muscle senescence.
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