Evidence map›Paper›PMID 23966978›Full record

ArticleFrontiers in endocrinology2013

Shift work and circadian dysregulation of reproduction.

Karen L Gamble, David Resuehr, Carl Hirschie Johnson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 8 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 8 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Karen L GambleDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham , Birmingham, AL , USA.
David Resuehr
Carl Hirschie Johnson
Vanderbilt University · USUniversity of Alabama at Birmingham · US

Funding

UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
Circadian dysfunction and neurodegenerative diseaseR01NS082413 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMBLE, KAREN L · 2013 to 2022
$4.6M
Circadian Programs in BacteriaR01GM067152 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2003 to 2014
$3.9M
Experimental Evolution of Circadian OscillatorsR01GM088595 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2009 to 2012
$1.2M
Integration of photic and nonphotic signaling in the circadian pacemakerR00GM086683 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMBLE, KAREN L · 2009 to 2011
$740k
Analysis of Mammalian Circadian Mechanism with Cell-permeant Clock ProteinsR21HL102492 · NHLBI · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2010 to 2011
$414k
NCATS NIH HHS UL1 TR000165NHLBI NIH HHS R21 HL102492NIGMS NIH HHS R00 GM086683NIGMS NIH HHS R01 GM067152NIGMS NIH HHS R01 GM088595NINDS NIH HHS R01 NS082413
6 · The paper itself

Abstract

Health impairments, including reproductive issues, are associated with working nights or rotating shifts. For example, shift work has been associated with an increased risk of irregular menstrual cycles, endometriosis, infertility, miscarriage, low birth weight or pre-term delivery, and reduced incidence of breastfeeding. Based on what is known about circadian regulation of endocrine rhythms in rodents (and much less in humans), the circadian clock is an integral regulatory part of the reproductive system. When this 24-h program is disordered by environmental perturbation (such as shift work) or genetic alterations, the endocrine system can be impaired. The purpose of this review is to explore the hypothesis that misalignment of reproductive hormones with the environmental light-dark cycle and/or sleep-wake rhythms can disrupt menstrual cycles, pregnancy, and parturition. We highlight the role of the circadian clock in regulating human reproductive physiology and shift work-induced pathology within each step of the reproductive axis while exploring potential mechanisms from the animal model literature. In addition to documenting the reproductive hazards of shift work, we also point out important gaps in our knowledge as critical areas for future investigation. For example, future studies should examine whether forced desynchronization disrupts gonadotropin secretion rhythms and whether there are sleep/wake schedules that are better or worse for the adaptation of the reproductive system to shift work. These studies are necessary in order to define not only whether or not shift work-induced circadian misalignment impairs reproductive capacity, but also to identify strategies for the future that can minimize this desynchronization.

Indexed as

circadian disruptionendocrinologyinfertilitymisalignmentpregnancy failuresleep

Identifiers

PMID23966978
PMCPMC3736045
OpenAlexW1969180181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.