ArticleFrontiers in psychiatry2013
A cross-sectional analysis of the development of response inhibition in children with chromosome 22q11.2 deletion syndrome.
Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Intraindividual Variability in Attention-Deficit/Hyperactivity Disorder: An Ex-Gaussian Approach.Child psychiatry and human development · 2026Article
- How Do Executive Functions Influence Children's Reasoning About Counterintuitive Concepts in Mathematics and Science?Journal of cognitive enhancement : towards the integration of theory and practice · 2023Article
- Atypical attentional filtering of visual information in youth with chromosome 22q11.2 deletion syndrome as indexed by event-related potentials.NeuroImage. Clinical · 2021Article
- Neural and behavioral measures suggest that cognitive and affective functioning interactions mediate risk for psychosis-proneness symptoms in youth with chromosome 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2020Article
- Goal-Directed-Behavior in 22q11.2 Deletion Syndrome: Implication for Social Dysfunctions and the Emergence of Negative Symptoms.Frontiers in psychiatry · 2020Article
- Atypical response inhibition and error processing in 22q11.2 Deletion Syndrome and schizophrenia: Towards neuromarkers of disease progression and risk.NeuroImage. Clinical · 2020Article
- Temporally sensitive neural measures of inhibition in preschool children across a spectrum of irritability.Developmental psychobiology · 2019Article
- Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions.Human brain mapping · 2017Article
- Reduced Efficiency and Capacity of Cognitive Control in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2016Article
- Developmental trajectories of executive functions in 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2016Article
- Behavioral and Psychiatric Phenotypes in 22q11.2 Deletion Syndrome.Journal of developmental and behavioral pediatrics : JDBP · 2015Review
- Cognitive ability is associated with altered medial frontal cortical circuits in the LgDel mouse model of 22q11.2DS.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.NeuroImage. Clinical · 2015Article
- Pre-pulse inhibition and antisaccade performance indicate impaired attention modulation of cognitive inhibition in 22q11.2 deletion syndrome (22q11DS).Journal of neurodevelopmental disorders · 2014Article
- The development of cognitive control in children with chromosome 22q11.2 deletion syndrome.Frontiers in psychology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with cognitive impairments and significantly elevated risk for developing schizophrenia. While impairments in response inhibition are central to executive dysfunction in schizophrenia, the nature and development of such impairments in children with 22q11.2DS, a group at high risk for the disorder, are not clear. Here we used a classic Go/No-Go paradigm to quantify proactive (anticipatory stopping) and reactive (actual stopping) response inhibition in 47 children with 22q11.2DS and 36 typically developing (TD) children, all ages 7-14. A cross-sectional design was used to examine age-related associations with response inhibition. When compared with TD individuals, children with 22q11.2DS demonstrated typical proactive response inhibition at all ages. By contrast, reactive response inhibition was impaired in children with 22q11.2DS relative to TD children. While older age predicted better reactive response inhibition in TD children, there was no age-related association with reactive response inhibition in children with 22q11.2DS. Closer examination of individual performance data revealed a wide range of performance abilities in older children with 22q11.2DS; some typical and others highly impaired. The results of this cross-sectional analysis suggest an impaired developmental trajectory of reactive response inhibition in some children with 22q11.2DS that might be related to atypical development of neuroanatomical systems underlying this cognitive process. As part of a larger study, this investigation might help identify risk factors for conversion to schizophrenia and lead to early diagnosis and preventive intervention.
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