ArticleFrontiers in human neuroscience2013
Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 6 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 6 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Facial expression recognition deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic investigation of effects of phenotypic variant, task modality, geographical region and symptomatic specificity.Journal of neurology · 2023Pooled it
- Exploring the Relationship Between Deficits in Social Cognition and Neurodegenerative Dementia: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Evaluation of Discriminative Detection Abilities of Social Cognition Measures for the Diagnosis of the Behavioral Variant of Frontotemporal Dementia: a Systematic Review.Neuropsychology review · 2021Pooled it
- Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.Frontiers in neurology · 2021Pooled it
- Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research.Frontiers in neurology · 2021Pooled it
- Neurotransmitter-defined cerebral vulnerability patterns in frontotemporal lobar degeneration (FTLD).Journal of neurology · 2026Article
- Rich-club organization and functional brain network metrics during facial emotional processing: a task-based fMRI study.Behavioral and brain functions : BBF · 2026Article
- Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Theory of mind deficits in non-fluent primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration.Journal of Alzheimer's disease : JAD · 2025Article
- Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia.Alzheimer's research & therapy · 2024Article
- Cortical thickness modeling and variability in Alzheimer's disease and frontotemporal dementia.Journal of neurology · 2024Article
- Altered reward processing underpins emotional apathy in dementia.Cognitive, affective & behavioral neuroscience · 2023Article
- Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders.Journal of Alzheimer's disease : JAD · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Beta amyloid deposition and cognitive decline in Parkinson's disease: a study of the PPMI cohort.Molecular brain · 2022Article
- Measuring social cognition in frontotemporal lobar degeneration: a clinical approach.Journal of neurology · 2022Review
- Social cognition in the FTLD spectrum: evidence from MRI.Journal of neurology · 2022Review
- Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia.Brain sciences · 2021Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.