ArticlePLoS genetics2013
Generation of tandem direct duplications by reversed-ends transposition of maize ac elements.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Progresses of transposon research inSynthetic and systems biotechnology · 2026Review
- Genome-Wide Analysis of thePlants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of theFrontiers in plant science · 2026Article
- Acquisition of new function through gene duplication in the metallocarboxypeptidase family.Scientific reports · 2023Article
- Article
- Excision and reinsertion of Ac macrotransposons in maize.Genetics · 2022Article
- Convergent copy number increase of genes associated with freshwater colonization in fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The multiple fates of gene duplications: Deletion, hypofunctionalization, subfunctionalization, neofunctionalization, dosage balance constraints, and neutral variation.The Plant cell · 2022Article
- Article
- Rapid Detection of Transposon-Induced Genome Rearrangements.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Ectopic Expression of a Maize Gene Is Induced by Composite Insertions Generated Through Alternative Transposition.Genetics · 2020Article
- Large tandem duplications affect gene expression, 3D organization, and plant-pathogen response.Genome research · 2020Article
- Transposon-mediated telomere destabilization: a driver of genome evolution in the blast fungus.Nucleic acids research · 2020Article
- Small RNA-MediatedGenetics · 2020Article
- Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy.Nature communications · 2020Article
- GingerRoot: A Novel DNA Transposon Encoding Integrase-Related Transposase in Plants and Animals.Genome biology and evolution · 2019Article
- Extensive Tandem Duplication Events Drive the Expansion of the C1q-Domain-Containing Gene Family in Bivalves.Marine drugs · 2019Article
- Nonallelic homologous recombination events responsible for copy number variation within an RNA silencing locus.Plant direct · 2019Article
- Structure and Origin of theGenetics · 2017Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tandem direct duplications are a common feature of the genomes of eukaryotes ranging from yeast to human, where they comprise a significant fraction of copy number variations. The prevailing model for the formation of tandem direct duplications is non-allelic homologous recombination (NAHR). Here we report the isolation of a series of duplications and reciprocal deletions isolated de novo from a maize allele containing two Class II Ac/Ds transposons. The duplication/deletion structures suggest that they were generated by alternative transposition reactions involving the termini of two nearby transposable elements. The deletion/duplication breakpoint junctions contain 8 bp target site duplications characteristic of Ac/Ds transposition events, confirming their formation directly by an alternative transposition mechanism. Tandem direct duplications and reciprocal deletions were generated at a relatively high frequency (~0.5 to 1%) in the materials examined here in which transposons are positioned nearby each other in appropriate orientation; frequencies would likely be much lower in other genotypes. To test whether this mechanism may have contributed to maize genome evolution, we analyzed sequences flanking Ac/Ds and other hAT family transposons and identified three small tandem direct duplications with the structural features predicted by the alternative transposition mechanism. Together these results show that some class II transposons are capable of directly inducing tandem sequence duplications, and that this activity has contributed to the evolution of the maize genome.
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