ArticlePLoS genetics2013
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
Open access · goldAbstract read
In one paragraph
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 5 pooled it
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Pooled it
- Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.International journal of obesity (2005) · 2017Pooled it
- Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.American journal of human genetics · 2016Pooled it
- Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.Scientific reports · 2016Pooled it
- A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).PloS one · 2015Pooled it
- Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study.PloS one · 2016Trial
- Body composition, geography and ethnicity: understanding the associations with health.European journal of clinical nutrition · 2026Review
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Genome-Wide Association Study of Abdominal and Intramuscular Fat Deposition Traits in Huainan Yellow-Feathered Chickens.Animals : an open access journal from MDPI · 2025Article
- Article
- Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Current obesity reports · 2024Review
- Loss ofbioRxiv : the preprint server for biology · 2024Article
- Physical activity alters the effect of genetic determinants of adiposity on hypertension among individuals of European ancestry in the UKB.Scandinavian journal of medicine & science in sports · 2024Article
- Depot-specific mRNA expression programs in human adipocytes suggest physiological specialization via distinct developmental programs.PloS one · 2024Article
- Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip.PeerJ · 2024Article
- Genomic signatures of selection, local adaptation and production type characterisation of East Adriatic sheep breeds.Journal of animal science and biotechnology · 2023Article
- Research on Health Disparities: Strategies and Findings From the Black Women's Health Study.American journal of epidemiology · 2023Article
- Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.HGG advances · 2023Article
- Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats.Diabetes · 2023Article
- Sex Differences in Adiposity and Cardiovascular Diseases.International journal of molecular sciences · 2022Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
93 authors at 20 institutions in 3 countries.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Keri L Monda
Kira C Taylor
Leslie Lange
Ellen W Demerath
Walter Palmas
Mary K Wojczynski
Jaclyn C Ellis
Mara Z Vitolins
Simin Liu
George J Papanicolaou
Marguerite R Irvin
Luting Xue
Paula J Griffin
Michael A Nalls
Adebowale Adeyemo
Jiankang Liu
Guo Li
Edward A Ruiz-Narvaez
Wei-Min Chen
Fang Chen
Brian E Henderson
Robert C Millikan
Christine B Ambrosone
Sara S Strom
Xiuqing Guo
Jeanette S Andrews
Yan V Sun
Thomas H Mosley
Lisa R Yanek
Daniel Shriner
Talin Haritunians
Jerome I Rotter
Elizabeth K Speliotes
Megan Smith
Lynn Rosenberg
Josyf Mychaleckyj
Uma Nayak
Ida Spruill
W Timothy Garvey
Curtis Pettaway
Sarah Nyante
Elisa V Bandera
Angela F Britton
Alan B Zonderman
Laura J Rasmussen-Torvik
Yii-Der Ida Chen
Jingzhong Ding
Kurt Lohman
Stephen B Kritchevsky
Wei Zhao
Patricia A Peyser
Sharon L R Kardia
Edmond Kabagambe
Ulrich Broeckel
Guanjie Chen
Jie Zhou
Sylvia Wassertheil-Smoller
Marian L Neuhouser
Evadnie Rampersaud
Bruce Psaty
Charles Kooperberg
Joann E Manson
Lewis H Kuller
Heather M Ochs-Balcom
Karen C Johnson
Lara Sucheston
Jose M Ordovas
Julie R Palmer
Christopher A Haiman
Barbara McKnight
Barbara V Howard
Diane M Becker
Lawrence F Bielak
Yongmei Liu
Matthew A Allison
Struan F A Grant
Gregory L Burke
Sanjay R Patel
Pamela J Schreiner
Ingrid B Borecki
Michele K Evans
Herman Taylor
Michele M Sale
Virginia Howard
Christopher S Carlson
Charles N Rotimi
Mary Cushman
Tamara B Harris
Alexander P Reiner
L Adrienne Cupples
Kari E North
Caroline S Fox
Boston University · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USNational Human Genome Research Institute · USUniversity of Michigan · USCedars-Sinai Medical Center · USNational Institutes of Health · USUniversity of Washington · USVirginia Department of Health · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Mississippi Medical Center · USAlabama Department of Public Health · USJohns Hopkins University · USUniversity at Buffalo, State University of New York · USUniversity of Alabama at Birmingham Hospital · USUniversity of Minnesota · USUniversity of Southern California · USWashington University in St. Louis · US
Funding
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MTissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MGenetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MTargeting Tumor Microenvironment-Induced Therapy Resistance in Prostate Cancer Bone MetastasisP50CA140388 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI THOMPSON, TIMOTHY CHARLES · 2009 to 2022
$23.4MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MIntramural NIH HHS Z01 AG000513Intramural NIH HHS Z01 HG200362NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000150NCI NIH HHS CA1326792NCI NIH HHS CA140388NCI NIH HHS CA148085NCI NIH HHS CA54281NCI NIH HHS CA63464NCI NIH HHS CA68578NCI NIH HHS P50 CA058223NCI NIH HHS P50 CA140388NCI NIH HHS P50-CA58223NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA058420NCI NIH HHS R01CA058920NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA068578NCI NIH HHS R01 CA098663NCI NIH HHS R01CA098663NCI NIH HHS R01 CA100598NCI NIH HHS R01-CA100598NCI NIH HHS R01-CA63464NCI NIH HHS R37 CA054281NCI NIH HHS R37-CA54281NCI NIH HHS RC2 CA148085NCI NIH HHS U01 CA063464NCI NIH HHS UM1 CA164974NCRR NIH HHS 2M01RR010284NCRR NIH HHS M01 RR000052NCRR NIH HHS M01-RR000052NCRR NIH HHS M01 RR000080NCRR NIH HHS M01RR00080NCRR NIH HHS M01 RR010284NCRR NIH HHS P20 RR017696NCRR NIH HHS P20-RR-17696NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1-RR-024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1-RR-025005NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS HG004726NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004726NHGRI NIH HHS Z01HG200362NHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL071025-01A1NHLBI NIH HHS HL080295NHLBI NIH HHS HL085251NHLBI NIH HHS HL087652NHLBI NIH HHS HL087660NHLBI NIH HHS HL100245NHLBI NIH HHS HL105756NHLBI NIH HHS HL54471NHLBI NIH HHS HL54472NHLBI NIH HHS HL54473NHLBI NIH HHS HL54495NHLBI NIH HHS HL54496NHLBI NIH HHS HL54509NHLBI NIH HHS HL54515NHLBI NIH HHS HL58625-01A1NHLBI NIH HHS HL59684NHLBI NIH HHS N01-HB-72982NHLBI NIH HHS N01-HB-7299NHLBI NIH HHS N01-HB-72991NHLBI NIH HHS N01-HB-72992NHLBI NIH HHS N01-HB-72993NHLBI NIH HHS N01-HB-72995NHLBI NIH HHS N01-HB-72996NHLBI NIH HHS N01-HB-72997NHLBI NIH HHS N01-HB-72998NHLBI NIH HHS N01-HB-73000NHLBI NIH HHS N01-HB-73001NHLBI NIH HHS N01-HB-73002NHLBI NIH HHS N01-HB-73003NHLBI NIH HHS N01-HB-73004NHLBI NIH HHS N01-HB-73005NHLBI NIH HHS N01-HB-73006NHLBI NIH HHS N01-HB-97051NHLBI NIH HHS N01-HB-97053NHLBI NIH HHS N01-HB-97056NHLBI NIH HHS N01-HB-97058NHLBI NIH HHS N01-HB-97060NHLBI NIH HHS N01-HB-97061NHLBI NIH HHS N01-HB-97062NHLBI NIH HHS N01-HB-97064NHLBI NIH HHS N01-HB-97066NHLBI NIH HHS N01-HB-97068NHLBI NIH HHS N01-HB-97069NHLBI NIH HHS N01-HB-97070NHLBI NIH HHS N01-HB-97071NHLBI NIH HHS N01-HB-97072NHLBI NIH HHS N01-HB-97085NHLBI NIH HHS N01 HC005187NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC045134NHLBI NIH HHS N01 HC045204NHLBI NIH HHS N01 HC045205NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01-HC-05187NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01 HC095170NHLBI NIH HHS N01 HC095171NHLBI NIH HHS N01 HC095172NHLBI NIH HHS N01 HC-15103NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01-HC-35129NHLBI NIH HHS N01-HC-45133NHLBI NIH HHS N01-HC-45134NHLBI NIH HHS N01-HC-45204NHLBI NIH HHS N01-HC-45205NHLBI NIH HHS N01-HC-4804NHLBI NIH HHS N01-HC-48048NHLBI NIH HHS N01-HC-48049NHLBI NIH HHS N01-HC-48050NHLBI NIH HHS N01-HC-55015NHLBI NIH HHS N01-HC-55016NHLBI NIH HHS N01-HC-55018NHLBI NIH HHS N01-HC-550190NHLBI NIH HHS N01-HC-55020NHLBI NIH HHS N01-HC-55021NHLBI NIH HHS N01-HC-55022NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-65226NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N01-HC-85239NHLBI NIH HHS N01-HC-95095NHLBI NIH HHS N01-HC-95100NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95170NHLBI NIH HHS N01-HC-95171NHLBI NIH HHS N01-HC-95172NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS NIH HL 46380NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL059684NHLBI NIH HHS R01 HL071025NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01- HL-071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01-HL-071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01-HL-071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01-HL-071251NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01-HL-071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01-HL-071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01-HL-071259NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL087698NHLBI NIH HHS R01 HL087698-01NHLBI NIH HHS R01 HL087700NHLBI NIH HHS R01-HL-087700NHLBI NIH HHS R01 HL088215NHLBI NIH HHS R01-HL-088215NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01HL092577-01A1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL55673NHLBI NIH HHS RC1 HL100245NHLBI NIH HHS U01 HL053916NHLBI NIH HHS U01 HL053934NHLBI NIH HHS U01 HL053937NHLBI NIH HHS U01 HL053938NHLBI NIH HHS U01 HL053941NHLBI NIH HHS U01 HL054471NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054473NHLBI NIH HHS U01 HL054495NHLBI NIH HHS U01 HL054496NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U01 HL063429NHLBI NIH HHS U01 HL063463NHLBI NIH HHS U01 HL064360NHLBI NIH HHS U01 HL072518NHLBI NIH HHS U01 HL077813NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL72518NHLBI NIH HHS U10 HL054471NHLBI NIH HHS U10 HL054472NHLBI NIH HHS U10 HL054473NHLBI NIH HHS U10 HL054495NHLBI NIH HHS U10 HL054496NHLBI NIH HHS U10 HL054509NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG-023629NIA NIH HHS AG-027058NIA NIH HHS AG-15928NIA NIH HHS AG-20098NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG62101NIA NIH HHS N01AG62103NIA NIH HHS N01AG62106NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NIA NIH HHS # Z01-AG000513NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01-DK-075681NIDDK NIH HHS R01 DK084350NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01-DK-8925601NIEHS NIH HHS ES007784NIEHS NIH HHS P30 ES007784NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30-ES10126NIGMS NIH HHS S06GM008016-320107NIGMS NIH HHS S06GM008016-380111NIGMS NIH HHS T32 GM007092NIMHD NIH HHS MD002249NIMHD NIH HHS P20 MD006899NIMHD NIH HHS P60 MD002249NINDS NIH HHS U01 NS041588NINR NIH HHS NR0224103PHS HHS 24152PHS HHS 32100-2PHS HHS 32105-6PHS HHS 32108-9PHS HHS 32111-13PHS HHS 32115PHS HHS 32118PHS HHS 32119PHS HHS 32122PHS HHS 42107-26PHS HHS 42129-32PHS HHS 44221PHS HHS N01-H-97054WHI NIH HHS N01 WH022110
Abstract
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values<5.0 × 10(-6) were followed-up (stage 2) in AA with WC and with WHR. Additionally, we interrogated genomic regions of previously identified European ancestry (EA) WHR loci among AA. In joint analysis of association results including both Stage 1 and 2 cohorts, 2 SNPs demonstrated association, rs2075064 at LHX2, p = 2.24×10(-8) for WC-adjusted-for-BMI, and rs6931262 at RREB1, p = 2.48×10(-8) for WHR-adjusted-for-BMI. However, neither signal was genome-wide significant after double GC-correction (LHX2: p = 6.5 × 10(-8); RREB1: p = 5.7 × 10(-8)). Six of fourteen previously reported loci for waist in EA populations were significant (p<0.05 divided by the number of independent SNPs within the region) in AA studied here (TBX15-WARS2, GRB14, ADAMTS9, LY86, RSPO3, ITPR2-SSPN). Further, we observed associations with metabolic traits: rs13389219 at GRB14 associated with HDL-cholesterol, triglycerides, and fasting insulin, and rs13060013 at ADAMTS9 with HDL-cholesterol and fasting insulin. Finally, we observed nominal evidence for sexual dimorphism, with stronger results in AA women at the GRB14 locus (p for interaction = 0.02). In conclusion, we identified two suggestive loci associated with fat distribution in AA populations in addition to confirming 6 loci previously identified in populations of EA. These findings reinforce the concept that there are fat distribution loci that are independent of generalized adiposity.
Indexed as
Body Fat DistributionGenome-Wide Association StudyAdiposityBlack PeopleFemaleGenetic LociHumansMaleObesityPolymorphism, Single NucleotideWaist-Hip RatioWhite People
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC0
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.