ArticlePLoS computational biology2013
Simulating cortical development as a self constructing process: a novel multi-scale approach combining molecular and physical aspects.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Efficient simulation of neural development using shared memory parallelization.Frontiers in neuroinformatics · 2023Article
- Constructive connectomics: How neuronal axons get from here to there using gene-expression maps derived from their family trees.PLoS computational biology · 2022Article
- Creative Destruction: A Basic Computational Model of Cortical Layer Formation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- A generative growth model for thalamocortical axonal branching in primary visual cortex.PLoS computational biology · 2020Article
- eBrain: a Three Dimensional Simulation Tool to Study Drug Delivery in the Brain.Scientific reports · 2019Article
- Erratum: Notice of Republication: Simulating Cortical Development as a Self Constructing Process: A Novel Multi-Scale Approach Combining Molecular and Physical Aspects.PLoS computational biology · 2019Article
- Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures.Frontiers in neuroinformatics · 2018Article
- Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ.The Journal of comparative neurology · 2016Article
- Comments and General Discussion on "The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution".Frontiers in neuroanatomy · 2016Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
- REMOD: A Tool for Analyzing and Remodeling the Dendritic Architecture of Neural Cells.Frontiers in neuroanatomy · 2015Article
- Dendrite and Axon Specific Geometrical Transformation in Neurite Development.Frontiers in computational neuroscience · 2015Article
- Developmental self-construction and -configuration of functional neocortical neuronal networks.PLoS computational biology · 2014Article
- Context-aware modeling of neuronal morphologies.Frontiers in neuroanatomy · 2014Article
- Beyond boundaries--Eph:ephrin signaling in neurogenesis.Cell adhesion & migration · 2014Review
- Learning and stabilization of winner-take-all dynamics through interacting excitatory and inhibitory plasticity.Frontiers in computational neuroscience · 2014Article
- An in silico agent-based model demonstrates Reelin function in directing lamination of neurons during cortical development.PloS one · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current models of embryological development focus on intracellular processes such as gene expression and protein networks, rather than on the complex relationship between subcellular processes and the collective cellular organization these processes support. We have explored this collective behavior in the context of neocortical development, by modeling the expansion of a small number of progenitor cells into a laminated cortex with layer and cell type specific projections. The developmental process is steered by a formal language analogous to genomic instructions, and takes place in a physically realistic three-dimensional environment. A common genome inserted into individual cells control their individual behaviors, and thereby gives rise to collective developmental sequences in a biologically plausible manner. The simulation begins with a single progenitor cell containing the artificial genome. This progenitor then gives rise through a lineage of offspring to distinct populations of neuronal precursors that migrate to form the cortical laminae. The precursors differentiate by extending dendrites and axons, which reproduce the experimentally determined branching patterns of a number of different neuronal cell types observed in the cat visual cortex. This result is the first comprehensive demonstration of the principles of self-construction whereby the cortical architecture develops. In addition, our model makes several testable predictions concerning cell migration and branching mechanisms.
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