ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Encoding and representation of intranasal CO2 in the mouse olfactory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
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- Nasal airflow engages central olfactory processing and shapes olfactory percepts.Proceedings. Biological sciences · 2020Article
- Reactive Neuroblastosis in Huntington's Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain.Frontiers in cellular neuroscience · 2018Article
- Single-neuron responses to intraoral delivery of odor solutions in primary olfactory and gustatory cortex.Journal of neurophysiology · 2017Article
- A Multisensory Network for Olfactory Processing.Current biology : CB · 2015Article
- Coding of odor stimulus features among secondary olfactory structures.Journal of neurophysiology · 2015Article
- Compliant intracortical implants reduce strains and strain rates in brain tissue in vivo.Journal of neural engineering · 2015Article
- Same same but different. Different trigeminal chemoreceptors share the same central pathway.PloS one · 2015Article
- A temporal channel for information in sparse sensory coding.Current biology : CB · 2014Article
- The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes.Biomaterials · 2014Article
- A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models.Biomaterials · 2014Article
- Development of Superoxide Dismutase Mimetic Surfaces to Reduce Accumulation of Reactive Oxygen Species for Neural Interfacing Applications.Journal of materials chemistry. B · 2014Article
- Odorless trigeminal stimulus CO2 triggers response in the olfactory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Intranasal trigeminal sensory input, often perceived as a burning, tingling, or stinging sensation, is well known to affect odor perception. While both anatomical and functional imaging data suggest that the influence of trigeminal stimuli on odor information processing may occur within the olfactory cortex, direct electrophysiological evidence for the encoding of trigeminal information at this level of processing is unavailable. Here, in agreement with human functional imaging studies, we found that 26% of neurons in the mouse piriform cortex (PCX) display modulation in firing to carbon dioxide (CO2), an odorless stimulant with known trigeminal capacity. Interestingly, CO2 was represented within the PCX by distinct temporal dynamics, differing from those evoked by odor. Experiments with ascending concentrations of isopentyl acetate, an odorant known to elicit both olfactory and trigeminal sensations, resulted in morphing of the temporal dynamics of stimulus-evoked responses. Whereas low concentrations of odorant evoked responses upon stimulus onset, high concentrations of odorant and/or CO2 often evoked responses structured to stimulus offset. These physiological experiments in mice suggest that PCX neurons possess the capacity to encode for stimulus modality (olfactory vs trigeminal) by differential patterns of firing. These data provide mechanistic insights into the influences of trigeminal information on odor processing and place constraints on models of olfactory-trigeminal sensory integration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.