ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.The international journal of neuropsychopharmacology · 2016Pooled it
- Elevated activity of the mesolimbic dopamine system promotes feeding during pregnancy in mice.bioRxiv : the preprint server for biology · 2025Article
- Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance.NPJ science of food · 2025Article
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.Neuropharmacology · 2025Article
- d-Amphetamine and Feeding States Cohesively Affect Locomotion and Motor Neuron Response in Zebrafish Larvae.Brain and behavior · 2024Article
- Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice.Psychopharmacology · 2024Article
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.bioRxiv : the preprint server for biology · 2024Article
- Value-Driven Adaptations of Mesolimbic Dopamine Release Are Governed by Both Model-Based and Model-Free Mechanisms.eNeuro · 2024Article
- Dopamine neuron activity evoked by sucrose and sucrose-predictive cues is augmented by peripheral and central manipulations of glucose availability.The European journal of neuroscience · 2024Article
- Experimental biology can inform our understanding of food insecurity.The Journal of experimental biology · 2024Article
- Article
- Overlapping representations of food and social stimuli in VTA dopamine neurons.bioRxiv : the preprint server for biology · 2023Article
- Article
- Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.Current biology : CB · 2022Article
- Stimuli predicting high-calorie reward increase dopamine release and drive approach to food in the absence of homeostatic need.Nutritional neuroscience · 2022Article
- Developmental or adult-onset deletion of neurotensin receptor-1 from dopamine neurons differentially reduces body weight.Frontiers in neuroscience · 2022Article
- Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness-Resistant Inbred Strain.Behavioral sciences (Basel, Switzerland) · 2021Article
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.Neurobiology of disease · 2021Article
- The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa.Frontiers in psychiatry · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
Restriction of food intake increases the acquisition of drug abuse behavior and enhances the reinforcing efficacy of those drugs. However, the neurophysiological mechanisms responsible for the interactions between feeding state and drug use are largely unknown. Here we show that chronic mild food restriction increases the burst firing of dopamine neurons in the substantia nigra. Dopamine neurons from food-restricted mice exhibited increased burst firing in vivo, an effect that was enhanced by an injection of the psychomotor stimulant cocaine (10 mg/kg, i.p.). Food restriction also enhanced aspartic acid-induced burst firing of dopamine neurons in an ex vivo brain slice preparation, consistent with an adaptation occurring in the somatodendritic compartment and independent of a circuit mechanism. Enhanced burst firing persisted after 10 d of free feeding following chronic food restriction but was not observed following a single overnight fast. Whole-cell patch-clamp recordings indicated that food restriction also increased electrically evoked AMPAR/NMDAR ratios and increased D2 autoreceptor-mediated desensitization in dopamine neurons. These results identify dopamine neurons in the substantia nigra as a convergence point for the interactions between feeding state and drugs of abuse. Furthermore, increased glutamate transmission combined with decreased autoreceptor inhibition could work in concert to enhance drug efficacy in response to food restriction.
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