ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The ventral striato-pallidal pathway mediates the effect of predictive learning on choice between goal-directed actions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 60 citations in OpenAlex.
- Ventral Pallidum Cholinergic Neurons Respond to Reward and Signal Reward Value.bioRxiv : the preprint server for biology · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Article
- Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.Scientific reports · 2024Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Food cue reactivity: Neurobiological and behavioral underpinnings.Reviews in endocrine & metabolic disorders · 2022Review
- Neurologic Effects of Gadolinium Retention in the Brain after Gadolinium-based Contrast Agent Administration.Radiology · 2022Article
- Outcome devaluation by specific satiety disrupts sensory-specific Pavlovian-to-instrumental transfer.Frontiers in behavioral neuroscience · 2022Article
- Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption.Nature neuroscience · 2021Article
- Interfacing behavioral and neural circuit models for habit formation.Journal of neuroscience research · 2020Review
- Complementary Roles for Ventral Pallidum Cell Types and Their Projections in Relapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neural Networks With Motivation.Frontiers in systems neuroscience · 2020Article
- Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens.Nature communications · 2018Article
- Neural encoding of choice during a delayed response task in primate striatum and orbitofrontal cortex.Experimental brain research · 2018Article
- Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure.eLife · 2018Article
- Paradoxical accentuation of motivation following accumbens-pallidum disconnection.Neurobiology of learning and memory · 2018Article
- Pharmacological Blockade of Adenosine AFrontiers in pharmacology · 2018Article
- Ventral Pallidum Output Pathways in Context-Induced Reinstatement of Alcohol Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neural Activity in the Ventral Pallidum Encodes Variation in the Incentive Value of a Reward Cue.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The nucleus accumbens shell (NAc-S) plays an important role in the way stimuli that predict reward affect the performance of, and choice between, goal-directed actions in tests of outcome-specific Pavlovian-instrumental transfer (PIT). The neural processes involved in PIT downstream of the ventral striatum are, however, unknown. The NAc-S projects prominently to the ventral pallidum (VP), and in the current experiments, we assessed the involvement of the NAc-S to VP projection in specific PIT in rats. We first compared expression of the immediate-early gene c-Fos in the medial (VP-m) and lateral (VP-l) regions of the VP and in addition, used the retrograde tracer Fluoro-gold combined with c-Fos to assess the involvement of these pathways during PIT. Although there was no evidence of differential activation in neurons in the VP-l, the VP-m showed a selective increase in activity in rats tested for PIT compared with appropriate controls, as did NAc-S neurons projecting to the VP-m. To confirm that VP-m activity is important for PIT, we inactivated this region before test and found this inactivation blocked the influence of predictive learning on choice. Finally, to confirm the functional importance of the NAc-S to VP-m pathway we used a disconnection procedure, using asymmetrical inactivation of the NAc-S and either the ipsilateral or contralateral VP-m. Specific PIT was blocked but only by inactivation of the NAc-S and VP-m in contralateral hemispheres. These results suggest that the NAc-S and VP-m form part of a circuit mediating the effects of predictive learning on choice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.