ArticleJournal of clinical microbiology2013
Molecular characterization of herpes simplex virus 2 strains by analysis of microsatellite polymorphism.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Insights into Genomic Dynamics and Plasticity in the Monkeypox Virus from the 2022 Outbreak.International journal of molecular sciences · 2026Article
- The whole genome analysis of four Orf virus strains from Europe and South America.Virus evolution · 2026Article
- Genome-wide identification and characterization of microsatellite markers within the Avipoxviruses.3 Biotech · 2022Article
- Non-cytopathic herpes simplex virus type-1 isolated from acyclovir-treated patients with recurrent infections.Scientific reports · 2022Article
- Review
- Genotyping of Salmon Gill Poxvirus Reveals One Main Predominant Lineage in Europe, Featuring Fjord- and Fish Farm-Specific Sub-Lineages.Frontiers in microbiology · 2020Article
- Genomic, Recombinational and Phylogenetic Characterization of Global Feline Herpesvirus 1 Isolates.Virology · 2018Article
- Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study.PLoS medicine · 2017Article
- New strategies against drug resistance to herpes simplex virus.International journal of oral science · 2016Review
- Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding.Clinical microbiology reviews · 2016Review
- Genetic Diversity within Alphaherpesviruses: Characterization of a Novel Variant of Herpes Simplex Virus 2.Journal of virology · 2015Article
- Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.Journal of virology · 2015Article
- Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete 154-kbp linear double-stranded genomic DNA sequence of herpes simplex virus 2 (HSV-2), consisting of two extended regions of unique sequences bounded by a pair of inverted repeat elements, was published in 1998 and since then has been widely employed in a wide range of studies. Throughout the HSV-2 genome are scattered 150 microsatellites (also referred to as short tandem repeats) of 1- to 6-nucleotide motifs, mainly distributed in noncoding regions. Microsatellites are considered reliable markers for genetic mapping to differentiate herpesvirus strains, as shown for cytomegalovirus and HSV-1. The aim of this work was to characterize 12 polymorphic microsatellites within the HSV-2 genome by use of 3 multiplex PCR assays in combination with length polymorphism analysis for the rapid genetic differentiation of 56 HSV-2 clinical isolates and 2 HSV-2 laboratory strains (gHSV-2 and MS). This new system was applied to a specific new HSV-2 variant recently identified in HIV-1-infected patients originating from West Africa. Our results confirm that microsatellite polymorphism analysis is an accurate tool for studying the epidemiology of HSV-2 infections.
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