ArticleJournal of burn care & research : official publication of the American Burn Association
Genetic risk factors for hypertrophic scar development.
Article in Journal of burn care & research : official publication of the American Burn Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Treatment of traumatic hypertrophic scars and keloids: a systematic review of randomized control trials.Archives of dermatological research · 2023Pooled it
- Evaluating Silicone Gel Efficacy in Reducing Scar Formation Following Microscopic Inguinal Varicocelectomy: A Double-Blind Prospective Controlled Trial.International wound journal · 2025Trial
- Assessing Patient Priorities and Satisfaction Regarding Aesthetic Outcomes Following Autologous Breast Reconstruction.Aesthetic plastic surgery · 2026Article
- Within-Patient, Quasi-Experimental Clinical Trial to Assess the Immediate Effects of Paraffin Wax on Adult, Post-Burn Hypertrophic Scar.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Current therapeutic strategies and available research models for investigating hypertrophic scars.Frontiers in pharmacology · 2026Review
- Using Cutaneous Functional Units (CFUs) to Understand Burn Characteristics Associated With Range of Motion at Hospital Discharge in Adult Burn Survivors.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Location, Payer Type, and Gender as Drivers of Burn Scar Reconstruction Utilization: A Burn Model Systems National Database Study.Annals of plastic surgery · 2025Article
- Association of Genetic Variants at theInternational journal of molecular sciences · 2024Article
- miRSNP rs188493331: A key player in genetic control of microRNA-induced pathway activation in hypertrophic scars and keloids.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Practical management of hypertrophic scarring: the mayo clinic experience.Archives of dermatological research · 2024Article
- Comparing the Effectiveness of Glucocorticoids in Preventing Hypertrophic Scar Diagnosis in Burn Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Clarifying sleep characteristics and analyzing risk factors of sleep disorders to promote a predictive, preventive, and personalized medicine in patients with burn scars.The EPMA journal · 2023Article
- An Updated Review of Hypertrophic Scarring.Cells · 2023Review
- Biofabrication of Human Skin with Its Appendages.Advanced healthcare materials · 2022Review
- Chronic itch in African Americans: an unmet need.Archives of dermatological research · 2022Review
- Diagnosis, Treatment, and Management of Painful Scar: A Narrative Review.Journal of pain research · 2022Review
- A Scoping Review of the Methodology Used in Studies of Genetic Influences on the Development of Keloid or Hypertrophic Scarring in Adults and Children After Acute Wounding.Advances in wound care · 2021Article
- [Research advances on skin sweat gland regeneration induced by stem cells and tissue engineering].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Review
- Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients.Burns & trauma · 2021Article
- Sprayed cultured autologous keratinocytes in the treatment of severe burns: a retrospective matched cohort study.Annals of burns and fire disasters · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Hypertrophic scars (HTSs) occur in 30 to 72% patients after thermal injury. Risk factors include skin color, female sex, young age, burn site, and burn severity. Recent correlations between genetic variations and clinical conditions suggest that single-nucleotide polymorphisms (SNPs) may be associated with HTS formation. The authors hypothesized that an SNP in the p27 gene (rs36228499) previously associated with decreased restenosis after coronary stenting would be associated with lower Vancouver Scar Scale (VSS) measurements and decreased itching. Patient and injury characteristics were collected from adults with thermal burns. VSS scores were calculated at 4 to 9 months after injury. Genotyping was performed using real-time polymerase chain reaction. Logistic regression was used to determine risk factors for HTS as measured by a VSS score >7. Three hundred subjects had a median age of 39 years (range, 18-91); 69% were male and median burn size was 7% TBSA (range, 0.25-80). Consistent with literature, the p27 variant SNP had an allele frequency of 40%, but was not associated with reduced HTS formation or lower itch scores in any genetic model. HTS formation was associated with American Indian/Alaskan Native race (odds ratio [OR], 12.2; P = .02), facial burns (OR, 9.4; P = .04), and burn size ≥20% TBSA (OR, 1.99; P = .03). Although the p27 SNP may protect against vascular fibroproliferation, the effect cannot be generalized to cutaneous scars. This study suggests that American Indian/Alaskan Native race, facial burns, and higher %TBSA are independent risk factors for HTS. The American Indian/Alaskan Native association suggests that there are potentially yet-to-be-identified genetic variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.