ArticleHeart (British Cardiac Society)2013
Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study.
Article in Heart (British Cardiac Society), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 7 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Systematic review and meta-analysis of respiratory viral triggers for acute myocardial infarction and stroke.Cardiovascular research · 2025Pooled it
- Association between Influenza and COVID-19 Viruses and the Risk of Atherosclerosis: Meta-Analysis Study and Systematic Review.Advances in respiratory medicine · 2022Pooled it
- Protective effect of influenza vaccination on cardiovascular diseases: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies.Human vaccines & immunotherapeutics · 2018Pooled it
- Vaccines for preventing influenza in healthy adults.The Cochrane database of systematic reviews · 2018Pooled it
- Acute myocardial infarction and influenza: a meta-analysis of case-control studies.Heart (British Cardiac Society) · 2015Pooled it
- Influenza, influenza-like symptoms and their association with cardiovascular risks: a systematic review and meta-analysis of observational studies.International journal of clinical practice · 2015Pooled it
- The presence of fever in adults with influenza and other viral respiratory infections.Epidemiology and infection · 2017Trial
- Review
- Review
- Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference.EClinicalMedicine · 2025Article
- Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011-2018.The Journal of infectious diseases · 2024Article
- Associations Between Severe Influenza-Complicated Thromboembolism Events, Intensive Care Unit Stays and Mortality, and Associated Risk Factors: A Retrospective Cohort Study.Influenza and other respiratory viruses · 2024Article
- Prevalence of influenza and other acute respiratory illnesses in patients with acute myocardial infarction in Bangladesh: A cross-sectional study.Health science reports · 2024Article
- Association of recent respiratory illness and influenza with acute myocardial infarction among the Bangladeshi population: A case-control study.Epidemiology and infection · 2023Article
- Pleiotropic Effects of Influenza Vaccination.Vaccines · 2023Review
- What if flu vaccination is the most responsible thing to do for cardiovascular health in the upcoming season?European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Modelling the influenza disease burden in people aged 50-64 and ≥65 years in Australia.Influenza and other respiratory viruses · 2022Article
- Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis.Hamostaseologie · 2021Article
- Recommendations of the Italian society for infectious and tropical diseases (SIMIT) for adult vaccinations.Human vaccines & immunotherapeutics · 2021Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbundant, indirect epidemiological evidence indicates that influenza contributes to all-cause mortality and cardiovascular hospitalisations with studies showing increases in acute myocardial infarction (AMI) and death during the influenza season.
objectiveTo investigate whether influenza is a significant and unrecognised underlying precipitant of AMI.
designCase-control study.
settingTertiary referral hospital in Sydney, Australia, during 2008 to 2010. PATIENTS: Cases were inpatients with AMI and controls were outpatients without AMI at a hospital in Sydney, Australia.
main outcome measuresPrimary outcome was laboratory evidence of influenza. Secondary outcome was baseline self-reported acute respiratory tract infection.
resultsOf 559 participants, 34/275 (12.4%) cases and 19/284 (6.7%) controls had influenza (OR 1.97, 95% CI 1.09 to 3.54); half were vaccinated. None were recognised as having influenza during their clinical encounter. After adjustment, influenza infection was no longer a significant predictor of recent AMI. However, influenza vaccination was significantly protective (OR 0.55, 95% CI 0.35 to 0.85), with a vaccine effectiveness of 45% (95% CI 15% to 65%).
conclusionsRecent influenza infection was an unrecognised comorbidity in almost 10% of hospital patients. Influenza did not predict AMI, but vaccination was significantly protective but underused. The potential population health impact of influenza vaccination, particularly in the age group 50-64 years, who are at risk for AMI but not targeted for vaccination, should be further explored. Our data should inform vaccination policy and cardiologists should be aware of missed opportunities to vaccinate individuals with ischaemic heart disease against influenza.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.