ArticleBMC nephrology2013
Hyperphosphatemia is associated with anemia in adults without chronic kidney disease: results from the National Health and Nutrition Examination Survey (NHANES): 2005-2010.
Article in BMC nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025Review
- SERUM PHOSPHORUS AS A RISK FACTOR FOR CARDIOVASCULAR MORBIDITY IN TYPE 2 DIABETES MELLITUS PATIENTS.Acta clinica Croatica · 2025Article
- Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis.BMC pediatrics · 2025Article
- Influence of hydroxyurea on tubular phosphate handling in sickle cell nephropathy.Hematology, transfusion and cell therapy · 2024Article
- Article
- Determinants of hyperphosphatemia and its relation with hemoglobin levels among hemodialysis patients in two hospitals from Syria: a prospective cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Physiopathology of Phosphate Disorders.Advances in kidney disease and health · 2023Review
- Article
- ALKBH1 reduces DNA N6-methyladenine to allow for vascular calcification in chronic kidney disease.The Journal of clinical investigation · 2021Article
- Characterization of an active ingredient made of nanoscale iron(oxyhydr)oxide for the treatment of hyperphosphatemia.RSC advances · 2021Article
- Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth.BMC nutrition · 2021Article
- Review
- Examining the association between serum phosphate levels and leukocyte telomere length.Scientific reports · 2020Article
- Interaction of Serum Phosphate with Age as Predictors of Cardiovascular Risk Scores in Stable Renal Transplant Recipients.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Article
- Covariation between plasma phosphate and daytime cortisol in early Parkinson's disease.Brain and behavior · 2016Article
- Association between Vitamin D Deficiency and Anemia in Patients with End-Stage Renal Disease: A Cross-Sectional Study.Yonsei medical journal · 2016Article
- Hyperphosphatemia Management in Patients with Chronic Kidney Disease.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Review
- Serum phosphorus and association with anemia among a large diverse population with and without chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
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Abstract
backgroundHyperphosphatemia, serum phosphorus ≥ 4.4 mg/dL, is associated with increased risk for chronic kidney disease and cardiovascular disease. Previous studies have shown a weak association between dietary phosphorus intake and serum phosphorus concentrations. While much less common in the general population, hypophosphatemia (< 2.5 mg/dL) may be associated with metabolic syndrome and obesity.
methodsUsing three cycles from the National Health and Nutrition Examination Survey (NHANES) (2005-2010), this study evaluated independent risk factors for hyperphosphatemia and hypophosphatemia.
resultsRisk factors for hyperphosphatemia included higher adjusted calcium (OR 2.90, 95% CI 2.43-3.45), increasing cholesterol (OR 1.003, 95% CI 1.001-1.005), female gender (OR 1.61, 95% CI 1.39-1.87) and low hemoglobin (OR 1.52, 95% CI 1.17-1.98). Advanced age was protective (OR 0.98, 95% CI 0.977-0.987). Models that included fasting serum glucose found lower body mass index (BMI) to be protective (OR 0.97, 95% CI 0.96-0.99) and adjusting for serum vitamin D and parathyroid hormone removed the association with low hemoglobin and BMI. Risk factors for hypophosphatemia included the following protective factors: higher albumin (OR 0.56, 95% CI 0.35-0.93), higher BUN (OR 0.90, 95% CI 0.86, 0.95), corrected calcium (OR 0.38, 95% CI 0.23-0.63) and female gender (OR 0.47, 95% 0.24-0.94). In men, higher fasting glucose levels increased risk (OR 1.01, 95% CI 1.0004-1.01).
conclusionThis study is the first to show an association between low hemoglobin levels and increased risk for hyperphosphatemia among individuals without chronic kidney disease. We did not find any association between diabetes mellitus, increasing BMI or fasting glucose levels and hypophosphatemia.
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