ArticleJournal of negative results in biomedicine2013
Serotonin: a novel bone mass controller may have implications for alveolar bone.
Article in Journal of negative results in biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluation of the Effect of Escitalopram on Alveolar Bone Levels and Periodontal Parameters: A Case-Control Study.International journal of dentistry · 2025Article
- Association between multiple genetic polymorphisms and molar-incisor hypomineralization: a population-based study.Journal of applied oral science : revista FOB · 2025Article
- Comparison of Serotonin-Regulated Calcific Processes in Aortic and Mitral Valvular Interstitial Cells.ACS omega · 2021Article
- Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo.Materials (Basel, Switzerland) · 2021Article
- Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells.Life sciences · 2020Article
- Serotonin: A Potent Immune Cell Modulator in Autoimmune Diseases.Frontiers in immunology · 2020Review
- Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146.Scientific reports · 2019Article
- Artemisinin inhibits breast cancer-induced osteolysis by inhibiting osteoclast formation and breast cancer cell proliferation.Journal of cellular physiology · 2019Article
- Serotonin Transporter (Frontiers in genetics · 2019Article
- Effects of RANKL Knockdown by Virus-like Particle-Mediated RNAi in a Rat Model of Osteoporosis.Molecular therapy. Nucleic acids · 2018Article
- Serum serotonin levels and bone in rheumatoid arthritis patients.Rheumatology international · 2017Article
- Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities.Nutrition and metabolic insights · 2017Article
- The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.Journal of periodontal research · 2016Article
- In Vivo siRNA Delivery Using JC Virus-like Particles Decreases the Expression of RANKL in Rats.Molecular therapy. Nucleic acids · 2016Article
- Depression and Inflammatory Periodontal Disease Considerations-An Interdisciplinary Approach.Frontiers in psychology · 2016Article
- 5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway.Oncotarget · 2015Article
- Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats.Journal of applied oral science : revista FOBArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As recent studies highlight the importance of alternative mechanisms in the control of bone turnover, new therapeutic approaches can be envisaged for bone diseases and periodontitis-induced bone loss. Recently, it has been shown that Fluoxetine and Venlafaxine, serotonin re-uptake inhibitors commonly used as antidepressants, can positively or negatively affect bone loss in rat models of induced periodontitis. Serotonin is a neurotransmitter that can be found within specific nuclei of the central nervous system, but can also be produced in the gut and be sequestered inside platelet granules. Although it is known to be mainly involved in the control of mood, sleep, and intestinal physiology, recent evidence has pointed at far reaching effects on bone metabolism, as a mediator of the effects of Lrp5, a membrane receptor commonly associated with Wnt canonical signaling and osteoblast differentiation. Deletion of Lrp5 in mice lead to increased expression of Tryptophan Hydroxylase 1, the gut isoform of the enzyme required for serotonin synthesis, thus increasing serum levels of serotonin. Serotonin, in turn, could bind to HTR1B receptors on osteoblasts and stop their proliferation by activating PKA and CREB.Although different groups have reported controversial results on the existence of an Lrp5-serotonin axis and the action of serotonin in bone remodeling, there is convincing evidence that serotonin modulators such as SSRIs can affect bone turnover. Consequently, the effects of this drug family on periodontal physiology should be thoroughly explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.