ArticleNutrition research and practice2013
Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRα, IGF-2 and IGF-1R in the postnatal rat liver.
Article in Nutrition research and practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics: A Systematic Review and Meta-Analysis.Molecular nutrition & food research · 2020Pooled it
- Effects of paternal preconception exposure to conventional and biologic DMARDs on newborn outcomes.Arthritis research & therapy · 2025Article
- The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review.Nutrients · 2024Review
- Role of Folate in Liver Diseases.Nutrients · 2024Review
- Review
- Environmental Impact on Male (In)Fertility via Epigenetic Route.Journal of clinical medicine · 2020Review
- Folate-Dependent Cognitive Impairment Associated With Specific Gene Networks in the Adult Mouse Hippocampus.Frontiers in nutrition · 2020Article
- Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle.BMC genomics · 2019Article
- Early-Life Exposures and Risk of Diabetes Mellitus and Obesity.Current diabetes reports · 2018Review
- POHaD: why we should study future fathers.Environmental epigenetics · 2018Article
- A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance.Frontiers in cell and developmental biology · 2018Review
- Altered GNAS imprinting due to folic acid deficiency contributes to poor embryo development and may lead to neural tube defects.Oncotarget · 2017Article
- The role of micronutrients in the response to ambient air pollutants: Potential mechanisms and suggestions for research design.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Extending the Developmental Origins of Health and Disease theory: does paternal diet contribute to breast cancer risk in daughters?Breast cancer research : BCR · 2016Article
- Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health.Nature reviews. Urology · 2016Review
- DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia.Epigenomics · 2016Review
- Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels.The Journal of clinical endocrinology and metabolism · 2015Article
- A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effect of parental folate deficiency on the folate content, global DNA methylation, folate receptor-alpha (FRα), insulin-like-growth factor-2 (IGF-2) and -1 receptor (IGF-1R) in the liver and plasma homocysteine in the postnatal rat. Male and female rats were randomly fed a folic acid-deficient (paternal folate-deficient, PD and maternal folate-deficient, MD), or folic acid-supplemented diet (paternal folate-supplemented, PS and maternal-folate-supplemented, MS) for four weeks. They were mated and grouped accordingly: PSxMS, PSxMD, PDxMS, and PDxMD. Pups were killed on day 21 of lactation. The hepatic folate content was markedly reduced in the PDxMD and PSxMD and PDxMS as compared with the PSxMS group. The hepatic global DNA methylation was decreased in the PDxMS and PSxMD groups as much as in the PDxMD group, and all the three groups were significantly lower as compared to the PSxMS group. There were no significant differences in the hepatic FRα, IGF-2 and IGF-1R expressions among the groups. Positive correlations were found between the hepatic folate content and global DNA methylation and protein expressions of FRα, IGF-2 and IGF-1R, whereas an inverse correlation was found between hepatic folate content and plasma homocysteine level in the 3-week-old rat pup. The results of this study show that both paternal and maternal folate deficiency at mating can influence the folate content and global DNA methylation in the postnatal rat liver.
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Registered trials
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