ArticleBiomicrofluidics2013
Micro- and nanofluidic technologies for epigenetic profiling.
Article in Biomicrofluidics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.Nature communications · 2019Review
- Electrophoretic stretching and imaging of single native chromatin fibers in nanoslits.Biomicrofluidics · 2017Article
- Application of microfluidic technologies to human assisted reproduction.Molecular human reproduction · 2017Review
- Microfluidics for genome-wide studies involving next generation sequencing.Biomicrofluidics · 2017Review
- Dynamic simulations show repeated narrowing maximizes DNA linearization in elastomeric nanochannels.Biomicrofluidics · 2016Article
- Morphological plasticity of bacteria-Open questions.Biomicrofluidics · 2016Review
- Biofunctionalized nanoslits for wash-free and spatially resolved real-time sensing with full target capture.Biomicrofluidics · 2015Article
- Fracture fabrication of a multi-scale channel device that efficiently captures and linearizes DNA from dilute solutions.Lab on a chip · 2015Article
- Single molecule and single cell epigenomics.Methods (San Diego, Calif.) · 2015Review
- Fracture-based fabrication of normally closed, adjustable, and fully reversible microscale fluidic channels.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns.Lab on a chip · 2014Article
- Fracture-based micro- and nanofabrication for biological applications.Biomaterials science · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This short review provides an overview of the impact micro- and nanotechnologies can make in studying epigenetic structures. The importance of mapping histone modifications on chromatin prompts us to highlight the complexities and challenges associated with histone mapping, as compared to DNA sequencing. First, the histone code comprised over 30 variations, compared to 4 nucleotides for DNA. Second, whereas DNA can be amplified using polymerase chain reaction, chromatin cannot be amplified, creating challenges in obtaining sufficient material for analysis. Third, while every person has only a single genome, there exist multiple epigenomes in cells of different types and origins. Finally, we summarize existing technologies for performing these types of analyses. Although there are still relatively few examples of micro- and nanofluidic technologies for chromatin analysis, the unique advantages of using such technologies to address inherent challenges in epigenetic studies, such as limited sample material, complex readouts, and the need for high-content screens, make this an area of significant growth and opportunity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.