ArticleProceedings of the National Academy of Sciences of the United States of America2013
NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Lateral parabrachial nucleus astrocytes control food intake.Frontiers in endocrinology · 2024Article
- Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity.eLife · 2023Article
- Review
- Postconditioning with Sevoflurane or Propofol Alleviates Lipopolysaccharide-Induced Neuroinflammation but Exerts Dissimilar Effects on the NR2B Subunit and Cognition.Molecular neurobiology · 2021Article
- Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding.Nature communications · 2021Article
- Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating.Frontiers in psychiatry · 2019Article
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.Trends in neurosciences · 2018Review
- A High-fat, High-sugar 'Western' Diet Alters Dorsal Striatal Glutamate, Opioid, and Dopamine Transmission in Mice.Neuroscience · 2018Article
- Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms.Biological psychiatry · 2017Review
- Expanding frontiers in weight-control research explored by young investigators.The journal of physiological sciences : JPS · 2017Review
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia InjuryFrontiers in aging neuroscience · 2017Article
- Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.International journal of molecular sciences · 2016Review
- Eating in mice with gastric bypass surgery causes exaggerated activation of brainstem anorexia circuit.International journal of obesity (2005) · 2016Article
- GLP-1 and weight loss: unraveling the diverse neural circuitry.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor.American journal of physiology. Endocrinology and metabolism · 2015Article
- Glutamate Receptors in the Central Nucleus of the Amygdala Mediate Cisplatin-Induced Malaise and Energy Balance Dysregulation through Direct Hindbrain Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Appetite and body weight regulation after bariatric surgery.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Structure, production and signaling of leptin.Metabolism: clinical and experimental · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Diphtheria toxin-mediated, acute ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to anorexia and starvation within 7 d that is caused by hyperactivity of neurons within the parabrachial nucleus (PBN). Because NMDA glutamate receptors are involved in various synaptic plasticity-based behavioral modifications, we hypothesized that modulation of the NR2A and NR2B subunits of the NMDA receptor in PBN neurons could contribute to the anorexia phenotype. We observed by Western blot analyses that ablation of AgRP neurons results in enhanced expression of NR2B along with a modest suppression of NR2A. Interestingly, systemic administration of LiCl in a critical time window before AgRP neuron ablation abolished the anorectic response. LiCl treatment suppressed NR2B levels in the PBN and ameliorated the local Fos induction that is associated with anorexia. This protective role of LiCl on feeding was blunted in vagotomized mice. Chronic infusion of RO25-6981, a selective NR2B inhibitor, into the PBN recapitulated the role of LiCl in maintaining feeding after AgRP neuron ablation. We suggest that the accumulation of NR2B subunits in the PBN contributes to aphagia in response to AgRP neuron ablation and may be involved in other forms of anorexia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.