ArticleThe Journal of infectious diseases2014
Aging promotes B-1b cell responses to native, but not protein-conjugated, pneumococcal polysaccharides: implications for vaccine protection in older adults.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Do human B-1 lymphocytes truly exist?Frontiers in immunology · 2026Review
- Article
- Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis.Cell reports · 2024Article
- Noncanonical B Cells: Characteristics of Uncharacteristic B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Type I IFN Receptor Signaling on B Cells Promotes Antibody Responses to Polysaccharide Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis.Frontiers in immunology · 2022Article
- The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Ontogeny of human B1 cells.International journal of hematology · 2020Review
- An Adjuvant That Increases Protective Antibody Responses to Polysaccharide Antigens and Enables Recall Responses.The Journal of infectious diseases · 2019Article
- Human B-1 Cells and B-1 Cell Antibodies Change With Advancing Age.Frontiers in immunology · 2019Article
- CD22 Promotes B-1b Cell Responses to T Cell-Independent Type 2 Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination.PloS one · 2018Article
- Article
- Pneumococcal Capsular Polysaccharide Immunity in the Elderly.Clinical and vaccine immunology : CVI · 2017Review
- PD-1 Suppresses Development of Humoral Responses That Protect against Tn-Bearing Tumors.Cancer immunology research · 2016Article
- B-1 lymphocytes in mice and nonhuman primates.Annals of the New York Academy of Sciences · 2015Review
- PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- B1b cells recognize protective antigens after natural infection and vaccination.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The efficacy of different vaccines in protecting elderly individuals against Streptococcus pneumoniae infections is not clear. In the current study, aged mice (22-25 months old) exhibited significantly increased susceptibility to respiratory infection with serotype 3 S. pneumoniae relative to younger adult mice, regardless of whether mice were naive or immunized with native pneumococcal polysaccharide (PPS; Pneumovax23) or protein-PPS conjugate (Prevnar-13) vaccines. Nonetheless, Pneumovax-immunized aged mice developed limited bacteremia following respiratory challenge and exhibited significantly increased survival following systemic challenge relative to Prevnar-immune aged mice and young mice that had received either vaccine. This was explained by >10-fold increases in PPS-specific immunoglobulin G (IgG) levels in Pneumovax-immunized aged mice relative to other groups. Remarkably, PPS3-specific B-cell expansion, IgG switching, plasmablast differentiation, and spleen and bone marrow antibody-secreting cell frequencies were 10-fold higher in aged mice following Pneumovax immunization relative to young mice, due to significantly increased B-1b cell participation. In summary, this study highlights (1) the need to devise strategies to enhance respiratory immunity in aged populations, (2) the diverse responses young and aged populations generate to Pneumovax vs Prevnar vaccines, and (3) the potential value of exploiting B-1b cell responses in aged individuals for increased vaccine efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.