ArticleGut2014
Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding.
Article in Gut, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 132 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Eating Behaviour in Crohn's Disease
A Randomised Controlled Trial of a Duodenal Sleeve Bypass Device (EndoBarrier)Compared With Standard Medical Therapy for the Management of Obese Subjects With Type 2 Diabetes
Do Appetitive Gut Hormones Reduce Addictive and Eating Behaviours in Obesity, and Nicotine and Alcohol Dependence?
Evaluation and Follow up of Emotional Regulation, Cognition, Impulsivity and Reward System in Obesity, and Determination of Its Biopsychosocial Risk Factors: A Prospective Study of Obese Patients Before and After Bariatric Surgery
Who cites it
132 citing papers in PubMed, 4 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Taste Changes after Bariatric Surgery: a Systematic Review.Obesity surgery · 2018Pooled it
- The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review.International journal of obesity (2005) · 2015Pooled it
- Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents.Obesity surgery · 2018Trial
- Trial
- Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.The American journal of clinical nutrition · 2016Trial
- Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity.The Journal of clinical endocrinology and metabolism · 2016Trial
- Trial
- Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food.The American journal of clinical nutrition · 2014Trial
- The Impact of Vertical Sleeve Gastrectomy on Behavioral and Reward-Related Outcomes.Brain and behavior · 2026Article
- Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2026Review
- Changes in Hedonic Hunger and Problematic Eating Behaviors Following Bariatric Surgery: A Comparative Study of Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy.Healthcare (Basel, Switzerland) · 2026Article
- Salient cue reactivity and eating behaviors in ex-smokers, abstinent alcohol use disorder, and obesity.Frontiers in psychiatry · 2026Article
- Homeostatic Appetite and Hedonic Hunger 13 Years After Roux-en-Y Gastric Bypass: Potential Associations and Predictive Value in Determining Long-Term Weight Loss Outcomes.Obesity surgery · 2025Article
- Insights into the neurobiology of weight loss after bariatric surgery and GLP-1R agonists.Neuropharmacology · 2025Review
- The Contribution of the Brain-Gut Axis to the Human Reward System.Biomedicines · 2024Review
- Changes in Food Preferences Before and After Intragastric Balloon Placement.Obesity surgery · 2024Article
- Control of Eating Attributes and Weight Loss Outcomes over One Year After Sleeve Gastrectomy.Obesity surgery · 2024Article
- Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets.Nutrients · 2024Review
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesRoux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations.
designWe used functional MRI, eating behaviour and hormonal phenotyping to compare body mass index (BMI)-matched unoperated controls and patients after RYGB and BAND surgery for obesity.
resultsObese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumbens and hippocampus. This was associated with lower palatability and appeal of high-calorie foods and healthier eating behaviour, including less fat intake, in RYGB compared with BAND patients and/or BMI-matched unoperated controls. These differences were not explicable by differences in hunger or psychological traits between the surgical groups, but anorexigenic plasma gut hormones (GLP-1 and PYY), plasma bile acids and symptoms of dumping syndrome were increased in RYGB patients.
conclusionsThe identification of these differences in food hedonic responses as a result of altered gut anatomy/physiology provides a novel explanation for the more favourable long-term weight loss seen after RYGB than after BAND surgery, highlighting the importance of the gut-brain axis in the control of reward-based eating behaviour.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.