ArticleArchives of disease in childhood. Fetal and neonatal edition2014
Long-term developmental outcome of children with a fetal diagnosis of isolated inferior vermian hypoplasia.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Prenatal diagnosis of infratentorial anomalies: ultrasound, fetal MRI, and implications for counseling.Pediatric radiology · 2026Review
- Structural Posterior Fossa Malformations: MR Imaging and Neurodevelopmental Outcome.Diagnostics (Basel, Switzerland) · 2025Article
- Utility of Biometric Measurements from Fetal Magnetic Resonance Imaging for Improved Antenatal Diagnosis of Dandy-Walker Spectrum Posterior Fossa Lesions.Diagnostics (Basel, Switzerland) · 2025Article
- Prenatal assessment of brain malformations on neuroimaging: an expert panel review.Brain : a journal of neurology · 2024Review
- Speech and Language Delays Associated With New-Onset Seizures Revealing Dandy-Walker Variant.Cureus · 2024Article
- Effect of magnet strength on fetal brain biometry - a single-center retrospective MRI-based cohort study.Neuroradiology · 2023Article
- Long-Term Outcome of Neonatal Seizure withChildren (Basel, Switzerland) · 2023Article
- Fetal Neurology: From Prenatal Counseling to Postnatal Follow-Up.Diagnostics (Basel, Switzerland) · 2022Review
- Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study.PloS one · 2022Article
- Challenges in the pre- and post-natal diagnosis of posterior fossa cysts: A case report and review of historical evolution of descriptive terminologies.Surgical neurology international · 2022Review
- Long-term follow-up in a cohort of children with isolated corpus callosum agenesis at fetal MRI.Annals of clinical and translational neurology · 2021Article
- Evaluation of Posterior Fossa Biometric Measurements on Fetal MRI in the Evaluation of Dandy-Walker Continuum.AJNR. American journal of neuroradiology · 2021Article
- Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses.AJNR. American journal of neuroradiology · 2021Article
- Prenatal magnetic resonance imaging within the 26th week of gestation may predict the fate of isolated upward rotation of the cerebellar vermis: insights from a multicentre study.European radiology · 2020Observational
- Delayed fenestration of Blake's pouch with or without vermian hypoplasia: fetal MRI at 3 tesla versus 1.5 tesla.Cerebellum & ataxias · 2019Article
- Neurodevelopmental Correlates of Fetal Motor Behavior Assessed Using Cine MR Imaging.AJNR. American journal of neuroradiology · 2018Article
- Brain Injury in Neonates with Complex Congenital Heart Disease: What Is the Predictive Value of MRI in the Fetal Period?AJNR. American journal of neuroradiology · 2016Article
- Consensus paper: radiological biomarkers of cerebellar diseases.Cerebellum (London, England) · 2015Article
- Prevalence and spectrum of in utero structural brain abnormalities in fetuses with complex congenital heart disease.AJNR. American journal of neuroradiology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesIsolated inferior vermian hypoplasia (iiVH) is one of the most common fetal cerebellar anomalies presenting for fetal neurological counselling with controversial postnatal neurodevelopmental outcome. In the present study, we characterised the long-term neurodevelopmental outcome of prenatally diagnosed iiVH at school age. DESIGN AND PATIENTS: We prospectively followed 20 children with fetal MRI diagnosis of iiVH including their postnatal MRI result and developmental outcome at school age (mean 6.1 years±1.9 years SD) using a comprehensive age-appropriate developmental testing battery, which encompassed cognitive, language, social and behavioural domains. Parental stress level and socioeconomic status were also evaluated.
resultsAll children with postnatally confirmed iiVH had a normal neurodevelopmental outcome. A subgroup of children (2/20) who demonstrated cognitive delays and behavioural impairments had more extensive cerebellar malformation. Despite a normal developmental outcome, the parents of children with postnatally confirmed iiVH had higher parental stress compared with those parents whose children had normal postnatal MRI.
conclusionsChildren with postnatally confirmed iiVH show age appropriate functioning at school age. Postnatal MRI is important to confirm the diagnosis of iiVH and to exclude associated anomalies that impact neurodevelopmental outcome. A diagnosis of iiVH is associated with persistent elevated parental stress despite normal developmental outcomes in these children suggesting the need for ongoing parental support.
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