ArticleGenetica2013
Relationship between 5' UTR length and gene expression pattern in chicken.
Article in Genetica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- The patterns of alternative TSS usage explain the highly heterogeneous landscape of 5'UTR lengths in eukaryotes.NAR genomics and bioinformatics · 2025Article
- Transcription initiation of distant core promoters in a large-sized genome of an insect.BMC biology · 2021Article
- Article
- Variable protein homeostasis in housekeeping and non-housekeeping pathways under mycotoxins stress.Scientific reports · 2019Article
- Estimating the parameters of background selection and selective sweeps inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Translational control of gene expression in the gonadotrope.Molecular and cellular endocrinology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chicken (Gallus gallus) is an important model organism that bridges the evolutionary gap between mammals and non-amniote vertebrates. Here, we carried out a systematic study of the relationship between 5' UTR length and gene expression pattern in the chicken genome. We found that gene 5' UTRs lengths show a negative correlation with gene expression levels and gene expression breadths significantly. The relevance of 5' UTR length to expression pattern can not be a consequence of transcription-associated mutations. We also found that gene 5' UTR length shows a weakly positive correlation with gene tissue specificity. Another intriguing finding is that genes with 5' UTR length <30 bp have highest expression level, highest expression breadth, and lowest tissue specificity in chicken. We argued that selection is likely involved in shaping 5' UTR length in the chicken genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.