SynthesisThe Cochrane database of systematic reviews2013
Probiotics for treating persistent diarrhoea in children.
Synthesis in The Cochrane database of systematic reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Probiotics for preventing acute upper respiratory tract infections.The Cochrane database of systematic reviews · 2022Pooled it
- Treatment interventions for diarrhoea in HIV-infected and HIV-exposed children: a systematic review.The Pan African medical journal · 2018Pooled it
- Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials.Frontiers in cellular and infection microbiology · 2017Pooled it
- High-dose multi-strain Bacillus probiotics enhance treatment and reduce antibiotic usage in children with persistent diarrhea through immune and microbiota modulation.Scientific reports · 2025Trial
- Promising clinical and immunological efficacy of Bacillus clausii spore probiotics for supportive treatment of persistent diarrhea in children.Scientific reports · 2024Trial
- Trial
- Fermented Milk Consumption and Common Infections in Children Attending Day-Care Centers: A Randomized Trial.Journal of pediatric gastroenterology and nutrition · 2016Trial
- New Drugs on the Block: Dietary Management and Nutritional Considerations During the Use of Anti-Obesity Medication.Nutrients · 2026Review
- Unraveling the Nutritional Perspectives of Probiotics and Prebiotics in Female Healthcare.Recent advances in food, nutrition & agriculture · 2026Review
- Early-Life Demographic Factors Shape Gut Microbiome Patterns Associated with Rotavirus Gastroenteritis Severity.Viruses · 2025Article
- Genomic and Phenotypic Safety Assessment of Probiotic Bacillus coagulans Strain JBI-YZ6.3.Probiotics and antimicrobial proteins · 2025Article
- Enabling technologies for in situ biomanufacturing using probiotic yeast.Advanced drug delivery reviews · 2025Review
- Maternal oral supplementation withFrontiers in nutrition · 2025Article
- Pathogen-Specific Benefits of Probiotic and Synbiotic Use in Childhood Acute Gastroenteritis: An Updated Review of the Literature.Nutrients · 2023Review
- Current use of complementary and conventional medicine for treatment of pediatric patients with gastrointestinal disorders.Frontiers in pharmacology · 2023Review
- Review
- Review
- Three reasons why expanded use of natural enemy solutions may offer sustainable control of human infections.People and nature (Hoboken, N.J.) · 2022Article
- Health Professionals' Knowledge of Probiotics: An International Survey.International journal of environmental research and public health · 2019Article
- With Probiotics, Resistance Is Not Always Futile.Cell host & microbe · 2018Article
Corrections and comments
- Update of
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent diarrhoea (diarrhoea lasting more than 14 days) accounts for one third of all diarrhoea related deaths in developing countries in some studies. Probiotics may help treatment.
objectivesTo evaluate probiotics for treating persistent diarrhoea in children. SEARCH
methodsWe searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, EMBASE, and LILACS. We also contacted authors of included trials and organizations working in the field, and checked reference lists. The date of the most recent search was 13 December 2012 SELECTION CRITERIA: Randomized controlled trials comparing a specified probiotic agent with placebo or no probiotic in children with persistent diarrhoea. DATA COLLECTION AND ANALYSIS: Two review authors assessed the eligibility, risk of bias, extracted and analysed data. Differences were resolved by discussion. Statistical analysis were performed using the fixed-effect model and the results were expressed as mean difference (MD) for continuous outcomes with 95% confidence intervals (CI). MAIN
resultsFour trials were included, with a total number of 464 participants; one trial had a low risk of bias. Meta-analysis showed that probiotics reduced the duration of persistent diarrhoea (mean difference 4.02 days, 95% CI 4.61 to 3.43 days, n = 324, two trials). Stool frequency was reduced with probiotics in two trials. One trial reported a shorter hospital stay, which was significant, but numbers were small. No adverse events were reported. AUTHORS'
conclusionsThere is limited evidence suggesting probiotics may be effective in treating persistent diarrhoea in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.