ArticleNucleic acids research2013
In situ visualization of telomere elongation patterns in human cells.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- RTEL1 mutation modifies dyskeratosis congenita caused by a telomerase RNA template mutation.Nature communications · 2026Article
- Intranucleolar Invasion of Cajal Body Remnants Suppresses Ribosomal Biogenesis inbioRxiv : the preprint server for biology · 2026Article
- Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase.Nature communications · 2025Article
- A persistent variant telomere sequence in a human pedigree.Nature communications · 2024Article
- The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats.Science advances · 2023Article
- TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.Science (New York, N.Y.) · 2022Article
- Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer.Nucleic acids research · 2022Article
- Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells.Cell reports · 2019Article
- Mechanisms of template handling and pseudoknot folding in human telomerase and their manipulation to expand the sequence repertoire of processive repeat synthesis.Nucleic acids research · 2018Article
- Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.Nature communications · 2018Article
- Telomerase can't handle the stress.Genes & development · 2018Article
- PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase.Genes & development · 2018Article
- Preliminary development of an assay for detection of TERT expression, telomere length, and telomere elongation in single cells.PloS one · 2018Article
- Preferential extension of short telomeres induced by low extracellular pH.Nucleic acids research · 2016Article
- The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.PLoS genetics · 2015Article
- Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1).Cancer cell international · 2015Article
- Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.Autophagy · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The telomerase enzyme plays a critical role in human aging and cancer biology by maintaining telomere length and extending the proliferative lifespan of most stem cells and cancer cells. Despite the importance of this enzyme, our understanding of the mechanisms that regulate its activity and establish telomere length homeostasis in mammalian cells is incomplete, in part because the perfect repetitive nature of telomeric sequence hampers in situ detection of telomere elongation patterns. Here, we describe a novel assay using a mutant telomerase that adds a well-tolerated variant telomeric repeat sequence to telomere ends. By specifically detecting the addition of these variant repeats, we can directly visualize telomere elongation events in human cells. We validate this approach by in situ mapping of telomere elongation patterns within individual nuclei and across a population of cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.