ReviewCurrent psychiatry reports2013
Altered brain reward circuits in eating disorders: chicken or egg?
Review in Current psychiatry reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Efficacy of transcranial magnetic stimulation in anorexia nervosa: a systematic review and meta-analysis.Eating and weight disorders : EWD · 2025Pooled it
- Prevalence of Eating Disorders in People With Borderline Personality Disorder: A Systematic Review and Meta-Analysis.Clinical psychology & psychotherapyPooled it
- The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.Psychological medicine · 2023Trial
- The Effect of Visual Capture Towards Subjective Embodiment Within the Full Body Illusion.Scientific reports · 2019Trial
- Regional gray matter alterations in anorexia nervosa: implications for subtype heterogeneity and clinical severity.Molecular psychiatry · 2026Article
- A scoping review on weight loss injections and eating disorders: therapeutic impact, risks of misuse, and emerging harms.Journal of eating disorders · 2026Review
- Non-invasive brain stimulation as an experimental treatment approach for bulimia nervosa and binge eating disorders: A meta-analysis and systematic review of literature.Indian journal of psychiatry · 2026Review
- Approved and Pipeline Pharmacological Interventions for Eating Disorders (2010-2025): 15 Years of Progress (or Lack Thereof).CNS drugs · 2026Review
- When tasty becomes threatening: a neurobehavioral perspective on subjective food preferences in eating disorders.Frontiers in psychology · 2026Review
- The Hidden Spectrum Within Eating Disorders: Clustering Neurodivergent Traits and Sensory Sensitivity.The International journal of eating disorders · 2025Article
- From Lab to Clinic and Farm: LeveragingBiology · 2025Review
- Effects of inpatient treatment of adolescents with anorexia nervosa are associated with body representation: a monocentric pilot study.Scientific reports · 2025Article
- Study protocol for a randomized, placebo-controlled, double-masked mechanistic clinical trial of transdermal estrogen replacement in hypoestrogenic eating disorders to explore the role of estrogen on cognitive flexibility and reward processing.Contemporary clinical trials · 2025Article
- Computational Perspectives on Cognition in Anorexia Nervosa: A Systematic Review.Computational psychiatry (Cambridge, Mass.) · 2025Review
- Ibogaine's potential role in supporting reward system recovery across diagnostic boundaries.Frontiers in pharmacology · 2025Article
- The Turkish validity and reliability of the Reward-Based Eating Drive (RED-13) Scale.PloS one · 2025Observational
- The adamant adherence to a prior belief: the case of anosognosia in anorexia nervosa.Frontiers in neurology · 2025Article
- Review
- Current perspectives on brain circuits involved in food addiction-like behaviors.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Psilocybin-assisted psychotherapy as a potential treatment for eating disorders: a narrative review of preliminary evidence.Trends in psychiatry and psychotherapy · 2024Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) are severe psychiatric disorders with high mortality. Our knowledge about the neurobiology of eating disorders is very limited, and the question remains whether alterations in brain structure or function in eating disorders are state related, remnants of the illness or premorbid traits. The brain reward system is a relatively well-characterized brain circuitry that plays a central role in the drive to eat and individuals with current or past eating disorders showed alterations in those pathways compared to controls. Here we propose that structural and functional alterations in the insula and frontal cortex, including orbitofrontal and cingulate regions, areas that contribute to reward and anxiety processing, could predispose to developing an eating disorder and that adaptive changes in those circuits in response to malnutrition or repeated binge eating and purging could further promote illness behavior, hinder recovery and contribute to relapse.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.