ArticleExperimental brain research2013
Effects of structural and functional cerebellar lesions on sensorimotor adaptation of saccades.
Article in Experimental brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Detrimental Effect of Stroke on Motor Adaptation.Neurorehabilitation and neural repair · 2025Pooled it
- Ganzfeld stimulation or sleep enhance long term motor memory consolidation compared to normal viewing in saccadic adaptation paradigm.PloS one · 2015Trial
- Adaptation of naturally paced saccades.Journal of neurophysiology · 2014Trial
- Cerebellar output shapes cortical preparatory activity during motor adaptation.Nature communications · 2025Article
- Cerebellar output shapes cortical preparatory activity during motor adaptation.bioRxiv : the preprint server for biology · 2025Article
- Classics to Contemporary of Saccadic Dysmetria and Oscillations.Cerebellum (London, England) · 2023Article
- Multiple step saccades are generated by internal real-time saccadic error correction.Frontiers in neuroscience · 2023Article
- Impaired Saccade Adaptation in Tremor-Dominant Cervical Dystonia-Evidence for Maladaptive Cerebellum.Cerebellum (London, England) · 2021Article
- Adaptive control of movement deceleration during saccades.PLoS computational biology · 2021Article
- The Psychology of Reaching: Action Selection, Movement Implementation, and Sensorimotor Learning.Annual review of psychology · 2021Review
- Investigating the effects of cerebellar transcranial direct current stimulation on saccadic adaptation and cortisol response.Cerebellum & ataxias · 2021Article
- Reduced Global-Brain Functional Connectivity of the Cerebello-Thalamo-Cortical Network in Patients With Dry Eye Disease.Frontiers in human neuroscience · 2020Article
- Cortico-cerebellar network involved in saccade adaptation.Journal of neurophysiology · 2018Article
- The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis.The Journal of physiology · 2017Article
- Sensorimotor adaptation as a behavioural biomarker of early spinocerebellar ataxia type 6.Scientific reports · 2017Article
- Saccadic adaptation to a systematically varying disturbance.Journal of neurophysiology · 2016Article
- Saccadic Adaptation in 10-41 Month-Old Children.Frontiers in human neuroscience · 2016Article
- Visual Space Constructed by Saccade Motor Maps.Frontiers in human neuroscience · 2016Review
- Adaptation and adaptation transfer characteristics of five different saccade types in the monkey.Journal of neurophysiology · 2015Article
- The role of the posterior cerebellum in saccadic adaptation: a transcranial direct current stimulation study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum is critically involved in the adaptation mechanisms that maintain the accuracy of goal-directed acts such as saccadic eye movements. Two categories of saccades, each relying on different adaptation mechanisms, are defined: reactive (externally triggered) saccades and voluntary (internally triggered) saccades. The contribution of the medio-posterior part of the cerebellum to reactive saccades adaptation has been clearly demonstrated, but the evidence that other parts of the cerebellum are also involved is limited. Moreover, the cerebellar substrates of voluntary saccades adaptation have only been marginally investigated. Here, we addressed these two questions by investigating the adaptive capabilities of patients with cerebellar or pre-cerebellar stroke. We recruited three groups of patients presenting focal lesions located, respectively, in the supero-anterior cerebellum, the infero-posterior cerebellum and the lateral medulla (leading to a Wallenberg syndrome including motor dysfunctions similar to those resulting from lesion of the medio-posterior cerebellum). Adaptations of reactive saccades and of voluntary saccades were tested during separate sessions in all patients and in a group of healthy participants. The functional lesion of the medio-posterior cerebellum in Wallenberg syndrome strongly impaired the adaptation of both reactive and voluntary saccades. In contrast, patients with lesion in the supero-anterior part of the cerebellum presented a specific adaptation deficit of voluntary saccades. Finally, patients with an infero-posterior cerebellar lesion showed mild adaptation deficits. We conclude that the medio-posterior cerebellum is critical for the adaptation of both saccade categories, whereas the supero-anterior cerebellum is specifically involved in the adaptation of voluntary saccades.
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