ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Lessons learned from MPI and physiologic testing in randomized trials of stable ischemic heart disease: COURAGE, BARI 2D, FAME, and ISCHEMIA.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01471522 (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- The value of core lab stress echocardiography interpretations: observations from the ISCHEMIA Trial.Cardiovascular ultrasound · 2015Trial
- SPECT myocardial perfusion imaging-based ischemia-guided early coronary revascularization improves survival: More fuel to the fire.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The eye cannot see what the mind does not know.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Revascularization versus drug therapy for coronary artery disease in patients aged over 80 years: a real-world study.Cardiovascular diagnosis and therapy · 2020Article
- Brazilian Cardiovascular Rehabilitation Guideline - 2020.Arquivos brasileiros de cardiologia · 2020Article
- Coronary Heart Disease: Have We Reached a Plateau in Primary Prevention?Journal of the American Heart Association · 2020Article
- Complete revascularization determined by myocardial perfusion imaging could improve the outcomes of patients with stable coronary artery disease, compared with incomplete revascularization and no revascularization.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- The elusive role of myocardial perfusion imaging in stable ischemic heart disease: Is ISCHEMIA the answer?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Outcome of revascularisation in stable coronary artery disease without ischaemia: a Danish registry-based follow-up study.BMJ open · 2017Observational
- The role of myocardial viability in contemporary cardiac practice.Heart failure reviews · 2017Review
- Revascularization and outcomes in Veterans with moderate to severe ischemia on myocardial perfusion imaging.Military Medical Research · 2017Article
- Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros.Journal of diabetes research · 2017Review
- Serial cardiac SPECT studies: Technical issues and clinical implications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Immortality time and serial myocardial perfusion imaging: Only those who do not die may repeat the exam.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Noninvasive Cardiac Imaging in Patients with Known and Suspected Coronary Artery Disease: What is in it for the Interventional Cardiologist?Current cardiology reports · 2016Review
- Evaluating left ventricular systolic dysfunction: Stress echocardiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Single-Photon Emission Computed Tomography Myocardial Ischemia Detection in High-Risk Asymptomatic Patients: Correlation with Coronary Calcium Score and High-Sensitivity C-Reactive Protein.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 16 institutions in 6 countries.
Funding
Abstract
There is a preponderance of evidence that, in the setting of an acute coronary syndrome, an invasive approach using coronary revascularization has a morbidity and mortality benefit. However, recent stable ischemic heart disease (SIHD) randomized clinical trials testing whether the addition of coronary revascularization to guideline-directed medical therapy (GDMT) reduces death or major cardiovascular events have been negative. Based on the evidence from these trials, the primary role of GDMT as a front line medical management approach has been clearly defined in the recent SIHD clinical practice guideline; the role of prompt revascularization is less precisely defined. Based on data from observational studies, it has been hypothesized that there is a level of ischemia above which a revascularization strategy might result in benefit regarding cardiovascular events. However, eligibility for recent negative trials in SIHD has mandated at most minimal standards for ischemia. An ongoing randomized trial evaluating the effectiveness of randomization of patients to coronary angiography and revascularization as compared to no coronary angiography and GDMT in patients with moderate-severe ischemia will formally test this hypothesis. The current review will highlight the available evidence including a review of the published and ongoing SIHD trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.