ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Evaluating gender differences in prognosis following SPECT myocardial perfusion imaging among patients with diabetes and known or suspected coronary disease in the modern era.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Prognostic value of normal stress myocardial perfusion imaging in diabetic patients: a meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Pooled it
- Sex-based differences in myocardial perfusion imaging among diabetic Egyptian patients:a retrospective registry study.Global cardiology science & practice · 2026Article
- Impact of sex and menopausal hormonal therapy on cardiovascular diseases in people with diabetes or prediabetes.Scientific reports · 2025Article
- Gender differences in outcome in patients with diabetes mellitus.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Myocardial perfusion imaging in women for the evaluation of stable ischemic heart disease-state-of-the-evidence and clinical recommendations.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious data suggested that diabetic women were at greater risk for future cardiac events than diabetic men. Increasing awareness of coronary artery disease (CAD) in women and advances in the management of CAD may have changed this paradigm.
objectiveTo investigate gender differences in prognosis among patients with diabetes who were clinically referred for single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI).
methodsPatients with diabetes undergoing SPECT-MPI from 1996 to 2006 were followed for 5 years or until cardiac death or non-fatal myocardial infarction. Clinical characteristics and nuclear parameters were compared with χ (2) and t tests. Multivariable Cox regression controlled for baseline differences and tested the impact of gender on survival.
resultsA total of 4,628 SPECT-MPI patients with diabetes (50% women, mean age 63 ± 12 years) were analyzed. There were 380 events, with rates higher in men (10% vs 7%, P < .001). Patients of either gender with abnormal scans had higher event rates than patients with normal scans. There were fewer cardiac events in diabetic females with no known CAD and normal scans compared to similar males (P = .044). However, diabetic males and females with known CAD had similar event rates for all degrees of perfusion abnormalities. Only age, history of heart failure, nuclear perfusion defect, and LVEF predicted survival; gender did not. LVEF ≤ 50% had the strongest association with cardiac events (hazard ratio = 2.518, 95% confidence interval, 1.922-3.298).
conclusionCardiovascular outcomes among patients with diabetes, regardless of a history of CAD, were similar in women and men. The size and severity of stress-induced perfusion abnormalities predicted outcomes equally in both genders.
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