ArticleScientific reports2013
Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Conserved functional features of natural killer cell subsets in chicken, human, and murine immune systems.iScience · 2025Article
- The immune system of chicken and its response to H9N2 avian influenza virus.The veterinary quarterly · 2023Review
- Co-administration of chicken IL-2 alleviates clinical signs and replication of the ILTV chicken embryo origin vaccine by pre-activating natural killer cells and cytotoxic T lymphocytes.Journal of virology · 2023Article
- Review
- NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics?Frontiers in immunology · 2023Review
- The Interplay betweenPathogens (Basel, Switzerland) · 2021Review
- Article
- Glucose Oligosaccharide and Long-Chain Glucomannan Feed Additives Induce Enhanced Activation of Intraepithelial NK Cells and Relative Abundance of Commensal Lactic Acid Bacteria in Broiler Chickens.Veterinary sciences · 2021Article
- The Evaluation of Cellular Immunity to Avian Viral Diseases: Methods, Applications, and Challenges.Frontiers in microbiology · 2021Review
- Article
- Natural killer cell responses to emerging viruses of zoonotic origin.Current opinion in virology · 2020Review
- Early Life Inoculation With Adult-Derived Microbiota Accelerates Maturation of Intestinal Microbiota and Enhances NK Cell Activation in Broiler Chickens.Frontiers in veterinary science · 2020Article
- Marek's Disease Virus Infection of Natural Killer Cells.Microorganisms · 2019Article
- Article
- Effects of Newcastle Disease Virus Infection on Chicken Intestinal Intraepithelial Natural Killer Cells.Frontiers in immunology · 2018Article
- The inflammatory response triggered by Influenza virus: a two edged sword.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Host genetics determine susceptibility to avian influenza infection and transmission dynamics.Scientific reports · 2016Article
- Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.PLoS pathogens · 2016Article
- Article
- Inflammatory responses to infection: the Dutch contribution.Immunology letters · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Infection of chickens with low pathogenicity avian influenza (LPAI) virus results in mild clinical signs while infection with highly pathogenic avian influenza (HPAI) viruses causes death of the birds within 36-48 hours. Since natural killer (NK) cells have been shown to play an important role in influenza-specific immunity, we hypothesise that NK cells are involved in this difference in pathogenicity. To investigate this, the role of chicken NK-cells in LPAI virus infection was studied. Next activation of lung NK cells upon HPAI virus infection was analysed. Infection with a H9N2 LPAI virus resulted in the presence of viral RNA in the lungs which coincided with enhanced activation of lung NK cells. The presence of H5N1 viruses, measured by detection of viral RNA, did not induce activation of lung NK cells. This suggests that decreased NK-cell activation may be one of the mechanisms associated with the enhanced pathogenicity of H5N1 viruses.
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Registered trials
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