ArticleJournal of visualized experiments : JoVE2013
Creating dynamic images of short-lived dopamine fluctuations with lp-ntPET: dopamine movies of cigarette smoking.
Article in Journal of visualized experiments : JoVE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Detecting and classifying neurotransmitter signals from ultra-high sensitivity PET data: the future of molecular brain imaging.Physics in medicine and biology · 2021Article
- Model Comparison Metrics Require Adaptive Correction if Parameters Are Discretized: Proof-of-Concept Applied to Transient Signals in Dynamic PET.IEEE transactions on medical imaging · 2020Article
- Selectivity of probes for PET imaging of dopamine D3 receptors.Neuroscience letters · 2019Review
- Time-dependent assessment of stimulus-evoked regional dopamine release.Nature communications · 2019Article
- Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction.Current opinion in behavioral sciences · 2018Article
- Evaluation of (-)-[Synapse (New York, N.Y.) · 2018Article
- News and views on in-vivo imaging of neurotransmission using PET and MRI.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2017Review
- A review of positron emission tomography studies exploring the dopaminergic system in substance use with a focus on tobacco as a co-variate.The American journal of drug and alcohol abuse · 2017Review
- Article
- Sex differences in the brain's dopamine signature of cigarette smoking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: sensitivity analysis and application to cigarette smoking in the PET scanner.Human brain mapping · 2014Article
- Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
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Authors and funding
7 authors.
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Abstract
We describe experimental and statistical steps for creating dopamine movies of the brain from dynamic PET data. The movies represent minute-to-minute fluctuations of dopamine induced by smoking a cigarette. The smoker is imaged during a natural smoking experience while other possible confounding effects (such as head motion, expectation, novelty, or aversion to smoking repeatedly) are minimized. We present the details of our unique analysis. Conventional methods for PET analysis estimate time-invariant kinetic model parameters which cannot capture short-term fluctuations in neurotransmitter release. Our analysis--yielding a dopamine movie--is based on our work with kinetic models and other decomposition techniques that allow for time-varying parameters. This aspect of the analysis--temporal-variation--is key to our work. Because our model is also linear in parameters, it is practical, computationally, to apply at the voxel level. The analysis technique is comprised of five main steps: pre-processing, modeling, statistical comparison, masking and visualization. Preprocessing is applied to the PET data with a unique 'HYPR' spatial filter that reduces spatial noise but preserves critical temporal information. Modeling identifies the time-varying function that best describes the dopamine effect on 11C-raclopride uptake. The statistical step compares the fit of our (lp-ntPET) model to a conventional model. Masking restricts treatment to those voxels best described by the new model. Visualization maps the dopamine function at each voxel to a color scale and produces a dopamine movie. Interim results and sample dopamine movies of cigarette smoking are presented.
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