To replicate or not to replicate: the case of pharmacogenetic studies: Establishing validity of pharmacogenomic findings: from replication to triangulation.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies.Clinical pharmacology and therapeutics · 2021
   Pooled it
2. Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.The pharmacogenomics journal · 2018
   Pooled it
3. The Beta-Blocker Pharmacogenetic Puzzle: More Pieces of Evidence for Pharmacodynamic Candidate Variants.Clinical and translational science · 2025
   Article
4. Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program.Frontiers in genetics · 2023
   Article
5. Pharmacogenomics, How to Deal with Different Types of Variants in Next Generation Sequencing Data in the Personalized Medicine Area.Journal of clinical medicine · 2020
   Review
6. The Association of Aquaporin-1 Gene with Marathon Running Performance Level: a Confirmatory Study Conducted in Male Hispanic Marathon Runners.Sports medicine - open · 2020
   Article
7. DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns.Clinical epigenetics · 2019
   Article
8. Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer.PloS one · 2018
   Article
9. Single-Subject Studies in Translational Nutrition Research.Annual review of nutrition · 2017
   Review
10. Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation.Environmental health perspectives · 2017
    Article
11. A Neighborhood-Wide Association Study (NWAS): Example of prostate cancer aggressiveness.PloS one · 2017
    Article
12. The Application of Genomics in Diabetes: Barriers to Discovery and Implementation.Diabetes care · 2016
    Article
13. Pharmacogenetics in Cardiovascular Medicine.Current genetic medicine reports · 2016
    Article
14. RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.Circulation. Cardiovascular genetics · 2016
    Article
15. Pharmacogenomics of hypertension and heart disease.Current hypertension reports · 2015
    Review
16. Genotype-based clinical trials in cardiovascular disease.Nature reviews. Cardiology · 2015
    Review
17. Pharmacogenomics in heart failure: where are we now and how can we reach clinical application?Cardiology in review
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as