ReviewCurrent topics in developmental biology2013
Temporal patterning of neural progenitors in Drosophila.
Review in Current topics in developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 103 citations in OpenAlex.
- Spatiotemporal control of myoblast identity drives muscle diversity in theScience advances · 2026Article
- Continuous negative autoregulation fine-tunes dosage-sensitive transcription factor expression to maintain post-mitotic neuron identity.bioRxiv : the preprint server for biology · 2026Article
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- Article
- Fate specification is spatially intermingled across planarian stem cells.Nature communications · 2023Article
- A circular RNA Edis-Relish-castor axis regulates neuronal development in Drosophila.PLoS genetics · 2022Article
- Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient ineLife · 2022Article
- Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity.Cell reports · 2022Article
- Hunchback prevents notch-induced apoptosis in the serotonergic lineage of Drosophila Melanogaster.Developmental biology · 2022Article
- Transcriptional and epigenetic regulation of temporal patterning in neural progenitors.Developmental biology · 2022Review
- A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.Developmental biology · 2021Review
- The role of cell lineage in the development of neuronal circuitry and function.Developmental biology · 2021Review
- Scalable control of developmental timetables by epigenetic switching networks.Journal of the Royal Society, Interface · 2021Article
- Time and space in segmentation.Interface focus · 2021Article
- Article
- Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning.International journal of molecular sciences · 2020Review
- A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells.Science advances · 2020Article
- Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system.PLoS genetics · 2020Article
- Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neurogenesis and Specification of Retinal Ganglion Cells.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila has recently become a powerful model system to understand the mechanisms of temporal patterning of neural progenitors called neuroblasts (NBs). Two different temporal sequences of transcription factors (TFs) have been found to be sequentially expressed in NBs of two different systems: the Hunchback, Krüppel, Pdm1/Pdm2, Castor, and Grainyhead sequence in the Drosophila ventral nerve cord; and the Homothorax, Klumpfuss, Eyeless, Sloppy-paired, Dichaete, and Tailless sequence that patterns medulla NBs. In addition, the intermediate neural progenitors of type II NB lineages are patterned by a different sequence: Dichaete, Grainyhead, and Eyeless. These three examples suggest that temporal patterning of neural precursors by sequences of TFs is a common theme to generate neural diversity. Cross-regulations, including negative feedback regulation and positive feedforward regulation among the temporal factors, can facilitate the progression of the sequence. However, there are many remaining questions to understand the mechanism of temporal transitions. The temporal sequence progression is intimately linked to the progressive restriction of NB competence, and eventually determines the end of neurogenesis. Temporal identity has to be integrated with spatial identity information, as well as with the Notch-dependent binary fate choices, in order to generate specific neuron fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.