ReviewCurrent opinion in structural biology2013
Correlative cryo-electron tomography and optical microscopy of cells.
Review in Current opinion in structural biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Multimodal FM-SEM dataset with millimetre-scale field of view for bundle-scale porosity and impregnation quantification in woven GFRP/PP composites.Data in brief · 2026Article
- Correlative voltage imaging and cryo-electron tomography bridge neuronal activity and molecular structure.Nature communications · 2025Article
- Article
- Integrated Fluorescence Microscopy (iFLM) for Cryo-FIB-milling and In-situ Cryo-ET.bioRxiv : the preprint server for biology · 2023Article
- Self-supervised learning for macromolecular structure classification based on cryo-electron tomograms.Frontiers in physiology · 2022Article
- Review
- Imaging Infection Across Scales of Size: From Whole Animals to Single Molecules.Annual review of microbiology · 2021Review
- CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy.Journal of structural biology · 2021Article
- Advances in Cryo-Correlative Light and Electron Microscopy: Applications for Studying Molecular and Cellular Events.The protein journal · 2019Review
- Ultrastructural cellular signatures: does cellular form follow function?National science review · 2019Article
- Review
- Improved deep learning-based macromolecules structure classification from electron cryo-tomograms.Machine vision and applications · 2018Article
- Biological Applications at the Cutting Edge of Cryo-Electron Microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2018Review
- Imaging analysis of the interface between osteoblasts and microrough surfaces of laser-sintered titanium alloy constructs.Journal of microscopy · 2018Article
- (Cryo)Transmission Electron Microscopy of Phospholipid Model Membranes Interacting with Amphiphilic and Polyphilic Molecules.Polymers · 2017Review
- Image-Based Chemical Structure Determination.Scientific reports · 2017Article
- X-ray ptychographic and fluorescence microscopy of frozen-hydrated cells using continuous scanning.Scientific reports · 2017Article
- New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography.Journal of structural biology · 2017Article
- Progress in imaging methods: insights gained into Plasmodium biology.Nature reviews. Microbiology · 2017Review
- Using integrated correlative cryo-light and electron microscopy to directly observe syntaphilin-immobilized neuronal mitochondriaBiophysics reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The biological processes occurring in a cell are complex and dynamic, and to achieve a comprehensive understanding of the molecular mechanisms underlying these processes, both temporal and spatial information is required. While cryo-electron tomography (cryoET) provides three-dimensional (3D) still pictures of near-native state cells and organelles at molecular resolution, fluorescence light microscopy (fLM) offers movies of dynamic cellular processes in living cells. Combining and integrating these two commonly used imaging modalities (termed correlative microscopy) provides a powerful means to not only expand the imaging scale and resolution but also to complement the dynamic information available from optical microscopy with the molecular-level, 3D ultrastructure detail provided by cryoET. As such, a correlative approach performed on a given specimen can provide high resolution snapshots of dynamic cellular events. In this article, I review recent advances in correlative light microscopy and cryoET and discuss major findings made available by applying this method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.