ArticleBMC infectious diseases2013
Proteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- MicroRNA 876-5p modulates EV-A71 replication through downregulation of host antiviral factors.Virology journal · 2020Article
- Exploration of vascular adhesion protein-1 expression in patients with conjunctivitis associated systemic lupus erythematosus using 2D-DIGE.Experimental and therapeutic medicine · 2019Article
- Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis.PLoS pathogens · 2018Article
- Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections.Scientific reports · 2016Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo clarify the molecular mechanisms that participate in the severe hand, foot and mouth disease (HFMD) infected by Enterovirus 71 and to detect any related protein biomarkers, we performed proteomic analysis of protein extracts from 5 extremely severe HFMD children and 5 healthy children.
methodsThe protein profiles of them were compared using two-dimensional electrophoresis. Differentially expressed proteins were identified using mass spectrometry. Functional classifications of these proteins were based on the PANTHER. The interaction network of the differentially expressed protein was generated with Pathway Studio.
resultsA total of 38 differentially expressed proteins were identified. Functional classifications of these proteins indicated a series of altered cellular processes as a consequence of the severe HFMD. These results provided not only new insights into the pathogenesis of severe HFMD, but also implications of potential therapeutic designs.
conclusionsOur results suggested the possible pathways that could be the potential targets for novel therapy: viral protection, complement system and peroxide elimination.
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