ArticleSpringerPlus2013
Haliscosamine: a new antifungal sphingosine derivative from the Moroccan marine sponge Haliclona viscosa.
Article in SpringerPlus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Bioactive Sphingosine from Ficus racemosa: Isolation, Structural Elucidation, DFT Studies and Cytotoxic Potential against Oral Carcinoma Cells Via in Vitro and in Silico Approaches.Applied biochemistry and biotechnology · 2026Article
- Review
- Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria.Scientific reports · 2021Article
- Marine-Derived Compounds and Prospects for Their Antifungal Application.Molecules (Basel, Switzerland) · 2020Review
- Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria.Scientific reports · 2017Article
- Activity of Haliscosamine against Fusarium oxysporum f.sp. melonis: in vitro and in vivo analysis.SpringerPlus · 2015Article
- Antifungal and antiviral products of marine organisms.Applied microbiology and biotechnology · 2014Review
- In vitro screening of antifungal activity of marine sponge extracts against five phytopathogenic fungi.SpringerPlus · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the aim of searching for new antifungal products from marine origin, we have isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa using bio-guided (antifungal) HPLC methods. The molecular structure of this compound was elucidated by spectrometric techniques IR, UV, MS and NMR. The isolated metabolite showed a significant antifungal activity against Cryptococcus and Candida species and a weak general toxicity in the brine shrimp lethality test. Further research is needed to study its in vivo activity, as well as to elucidate the mechanism underlying its activity in the hope of a future use in medical mycology.
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Registered trials
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