ArticleJournal of carcinogenesis2013
Mapping cancer cell metabolism with(13)C flux analysis: Recent progress and future challenges.
Article in Journal of carcinogenesis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Metabolite Profiling of Preneoplastic and Neoplastic Lesions of Oral Cavity Tissue Samples Revealed a Biomarker Pattern.Scientific reports · 2016Trial
- Article
- Oncometabolites in pancreatic cancer: Strategies and its implications.World journal of experimental medicine · 2024Review
- Metabolomic Profiling of Oral Potentially Malignant Disorders and Its Clinical Values.Biomedicines · 2024Review
- Metabolic flux reprogramming inFrontiers in microbiology · 2023Article
- Isotopic Tracer for Absolute Quantification of Metabolites of the Pentose Phosphate Pathway in Bacteria.Metabolites · 2022Review
- Article
- Review
- Protein kinase CK2-dependent aerobic glycolysis-induced lactate dehydrogenase A enhances the migration and invasion of cancer cells.Scientific reports · 2019Article
- Pyruvate Treatment Restores the Effectiveness of Chemotherapeutic Agents in Human Colon Adenocarcinoma and Pleural Mesothelioma Cells.International journal of molecular sciences · 2018Article
- Metabolic Analysis of Drosophila melanogaster Larval and Adult Brains.Journal of visualized experiments : JoVE · 2018Article
- Expanding the concepts of cancer metabolism.Experimental & molecular medicine · 2018Article
- Mass Spectrometry-Based Method to Study Inhibitor-Induced Metabolic Redirection in the Central Metabolism of Cancer Cells.Mass spectrometry (Tokyo, Japan) · 2018Article
- Temporal fluxomics reveals oscillations in TCA cycle flux throughout the mammalian cell cycle.Molecular systems biology · 2017Article
- Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism.Metabolic engineering · 2017Article
- Cancer Metabolomics and the Human Metabolome Database.Metabolites · 2016Review
- Cancer Metabolism and Drug Resistance.Metabolites · 2015Review
- Metabolome-Wide Analysis of Stable Isotope Labeling-Is It Worth the Effort?Frontiers in physiology · 2015Article
- Heterogeneity of glycolysis in cancers and therapeutic opportunities.Biochemical pharmacology · 2014Review
- OpenMebius: an open source software for isotopically nonstationary 13C-based metabolic flux analysis.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The reprogramming of energy metabolism is emerging as an important molecular hallmark of cancer cells. Recent discoveries linking specific metabolic alterations to cancer development have strengthened the idea that altered metabolism is more than a side effect of malignant transformation, but may in fact be a functional driver of tumor growth and progression in some cancers. As a result, dysregulated metabolic pathways have become attractive targets for cancer therapeutics. This review highlights the application of(13)C metabolic flux analysis (MFA) to map the flow of carbon through intracellular biochemical pathways of cancer cells. We summarize several recent applications of MFA that have identified novel biosynthetic pathways involved in cancer cell proliferation and shed light on the role of specific oncogenes in regulating these pathways. Through such studies, it has become apparent that the metabolic phenotypes of cancer cells are not as homogeneous as once thought, but instead depend strongly on the molecular alterations and environmental factors at play in each case.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.