Evidence map›Paper›PMID 23960916›Full record

ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society2011

Predicting visual outcomes for macular disease using optical coherence tomography.

Pearse A Keane, Srinivas R Sadda

Abstract read
In one paragraph

Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Hard exudates in diabetic macular edema after intravitreal anti-VEGF therapy: a post-hoc analysis of the DRCR protocol T trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  5. Evaluating an automated machine learning model that predicts visual acuity outcomes in patients with neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  6. Article
  7. Choroidal thickening in retinal vein occlusion patients with serous retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  8. The prognostic value of total macular external limiting membrane and ellipsoid zone damage for clinical outcome in treatment-resistant neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pearse A KeaneNIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, United Kingdom.
Srinivas R Sadda

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the management of macular disease has undergone radical changes, in part because of new therapeutic approaches, but also due to the introduction of a new imaging modality - optical coherence tomography (OCT). The application of OCT imaging has clarified many aspects of chorioretinal disease pathophysiology and elucidated many hitherto unrecognized disease characteristics. From an early stage in its development, OCT has also been revolutionary in attempting to extract clinically useful measurements from image data in an automated fashion. As a result, OCT-derived measurements of retinal thickness have been rapidly embraced in clinical and research settings. However, as knowledge of OCT image analysis has developed, it has become increasingly clear that even accurate measurements of retinal thickness may fail to predict visual outcomes for many diseases. As a result, the focus of much current clinical imaging research is on the identification of other OCT-derived anatomic biomarkers predictive of visual outcomes - such biomarkers could serve as surrogate endpoints in clinical trials and provide prognostic information in clinical practice. In this review, we begin by highlighting the importance of accurate visual function assessment and describing the fundamentals of OCT image evaluation, before describing the current state-of-the-art with regard to predicting visual outcomes, for a variety of macular diseases, using OCT.

Indexed as

Age-related macular degenerationAMD, age-related macular degenerationBRVO, branch retinal vein occlusionCentral serous chorioretinopathyCME, cystoid macular edemaCNV, choroidal neovascularizationContrast sensitivityCRVO, central retinal vein occlusionCSC, central serous chorioretinopathyDiabetic macular edemaDME, diabetic macular edemaELM, external limiting membraneERM, epiretinal membraneETDRS, Early Treatment Diabetic Retinopathy StudyGA, geographic atrophyGeographic atrophyIS–OS, inner segment–outer segmentlogMAR, logarithm of the minimum angle of resolutionMicroperimetryMPS, Macular Photocoagulation StudyOCT, optical coherence tomographyOptical coherence tomographyPED, pigment epithelium detachmentRPE, retinal pigment epitheliumSurrogate endpointsVisual acuity

Identifiers

PMID23960916
PMCPMC3729388

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.