ArticleJournal of the Saudi Heart Association2009
Inhibition of Na(+)-H(+) exchange before resuscitation following hemorrhagic shock is cardioprotective in rats.
Article in Journal of the Saudi Heart Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Insulin treatment before resuscitation following hemorrhagic shock improves cardiac contractility and protects the myocardium in the isolated rat heart.Journal of emergencies, trauma, and shockArticle
- Apelin protect against multiple organ injury following hemorrhagic shock and decrease the inflammatory response.International journal of applied & basic medical researchArticle
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1 author.
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Abstract
backgroundStimulation of the Na(+)-H(+) exchanger during resuscitation following hemorrhagic shock results in myocardial injury and dysfunction. Inhibition of the Na(+)-H(+) exchanger appears to be a new pharmacological tool for myocardial protection following ischemia-reperfusion. Our lab showed that inhibition of the Na(+)-H(+) exchanger, using amiloride and dimethyl amiloride, before ex vivo resuscitation of isolated perfused hearts protected the myocardium and improved the post-resuscitation myocardial function. The purpose of the present study was to examine the myocardial protective effects of treating the hemorrhagic shocked rats by intra-arterial injection of 20 μM dimethyl amiloride (DMA), a specific Na(+)-H(+) exchanger blocker, before in vivo resuscitation.
methodsSprague-Dawley rats were assigned to hemorrhagic treated or untreated groups (n = 4 per group). After 60 min of hemorrhagic shock, rats were treated or not by injection of 20 μM 5-(N,N-dimethyl)-amiloride (DMA) intra-arterially. Rats were then resuscitated in vivo and monitored for 30 min. Then hearts were harvested and perfused in the Langendorff system for 60 min for measurements of hemodynamic function.
resultsAdministration of DMA before in vivo resuscitation following 60 min of hemorrhagic shock and 30 min of in vivo resuscitation, 20 μM DMA intra-arterially significantly improved post-resuscitation myocardial function.
conclusionOur results suggest that DMA protects the heart against post-resuscitation myocardial injury.
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